STAT6 (EP325) Rabbit Monoclonal Antibody

STAT6
STAT6 (EP325) on solitary fibrous tumor.

STAT6 (EP325) Rabbit Monoclonal Antibody

Specialties: Soft Tissue Pathology

Updated: 2017-05-24 08:46:09

STAT6, a member of the signal transducers and activators of transcription (STAT) family, has been found to form recurrent fusions with NAB2 on chromosome 12q13 in the majority of solitary fibrous tumors.1-3 Inactivated STAT6 can be found in the form of a dimer located in the cytoplasm.1 STAT6 and NAB2 fusion enables cytosolic STAT6 to migrate to the nucleus and thus allowing for detection in immunohistochemical assays.1 NAB2-STAT6 fusion transcriptions have been reported in the majority of solitary fibrous tumors but not in meningiomas, hemangioblastomas, schwannomas, and hemangiomas.1-3 This makes STAT6 a useful marker in distinguishing solitary fibrous tumors from other morphologically similar tumors.

  1. Cheah AL, et al. Pathology. 2014; 46:389-95.
  2. Schweizer L, et al. Acta Neuropathol. 2013; 125:651-58.
  3. Koelsche C, et al. Histopathology. 2014; 65:613-22.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: solitary fibrous tumor
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate426R-14
0.5 mL concentrate426R-15
1 mL concentrate426R-16
1 mL predilute426R-17
7 mL predilute426R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate426R-14
0.5 mL concentrate426R-15
1 mL concentrate426R-16
1 mL predilute426R-17
7 mL predilute426R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate426R-14
0.5 mL concentrate426R-15
1 mL concentrate426R-16
1 mL predilute426R-17
7 mL predilute426R-18

For research use only (RUO) in Japan

0.1 mL concentrate426R-14-RUO
0.5 mL concentrate426R-15-RUO
1 mL concentrate426R-16-RUO
1 mL predilute426R-17-RUO
7 mL predilute426R-18-RUO

 

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