Olig2 (EP112) Rabbit Monoclonal Primary Antibody

Olig2
Olig2 (EP112) on oligodendroglioma.

Olig2 (EP112) Rabbit Monoclonal Primary Antibody

Specialties: Neuropathology

Updated: 2018-06-21 13:43:00

Olig2, a basic helix–loop–helix transcription factor, is involved in oligodendroglial specification. Olig2 expression has been reported in most glial tumors, such as oligodendrogliomas and astrocytomas1-2. Although more than half of glioblastomas are positive for Olig2, expression is very weak in terms of both percentage of labeled cells and intensity. No Olig2 expression has been found in the non-glial tumors including neuroepithelial tumors, ependymomas, subependymomas, medulloblastomas, and nonneuroepithelial tumors, such as CNS lymphomas, meningiomas, schwannomas, atypical teratoid/rhabdoid tumor, and haemangioblastomas1-2. Compared to the strong staining seen in glioma samples, a weak expression is observed in non-tumoral brain tissue (gliosis).

  1. Mokhtari K, et al. Olig2 expression, GFAP, p53 and 1p loss analysis contribute to glioma subclassification. Neuropathol Appl Neurobiol. 2005; 31:62-9.
  2. Otero JJ, et al. OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms. J Neurooncol. 2011; 104:423-438.

Specifications


  • Reactivity: paraffin
  • Control: Astrocytoma (Nuclear)
  • Dilution Range: 1:50-1:200 *

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate387R-14
0.5 mL concentrate387R-15
1.0 mL concentrate387R-16
1.0 mL predilute ready-to-use387R-17
7.0 mL predilute ready-to-use387R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate387R-14
0.5 mL concentrate387R-15
1.0 mL concentrate387R-16
1.0 mL predilute ready-to-use387R-17
7.0 mL predilute ready-to-use387R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate387R-14
0.5 mL concentrate387R-15
1.0 mL concentrate387R-16
1.0 mL predilute ready-to-use387R-17
7.0 mL predilute ready-to-use387R-18

This product is not available in Japan

 

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