Cell Marque Portfolio

NKX3.1 (EP356)

Rabbit Monoclonal


NKX3.1 is a prostate specific androgen-regulated homeobox gene located on chromosome 8.1,2,3 It is difficult to distinguish between high grade prostate adenocarcinoma and high grade infiltrating urothelial carcinoma using hematoxylin and eosin stained specimens.2 Current prostate adenocarcinoma markers such as PSA and PSAP are very useful in determining prostate origin of prostate cancer in other sites, but have lower sensitivity when identifying poorly differentiated compared to well differentiated cases.2 Currently, thrombomodulin and uroplakin are used to identify tumors of urothelial origin; however, their sensitivities are suboptimal.2 In a study by Gurel et al., nearly all cases of metastatic prostate adenocarcinoma were stained by NKX3.1.1 NKX3.1-positive prostate carcinoma cells exhibit nuclear staining.1In another study conducted by Chuang et al., nearly all cases of urothelial carcinoma were negative for NKX3.1.2 Lastly, NKX3.1 has also been found to be expressed in invasive ductal carcinomas (IDC) and invasive lobular carcinomas (ILC) of the breast.3 NKX3.1 expression is limited to ER, PR, and AR positive carcinomas and is more frequently expressed in ILC than IDC.3 NKX3.1 has a high specificity and sensitivity for prostate adenocarcinomas and can be used to help distinguish between prostate carcinoma and urothelial carcinomas.1,2

Specialties: Anatomic Pathology Genitourinary (GU) Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: prostate adenocarcinoma, prostate
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10minAb/HiDef/Perm Red

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Last updated: 2016-09-29 13:18:40

NKX3.1
Nuclear labelling by anti-NKX3.1 on high-grade prostate carcinoma.

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Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: prostate adenocarcinoma, prostate
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10minAb/HiDef/Perm Red

Download an IFU

Select revision:


Download SDS


Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 441R-14
0.5 ml, concentrate 441R-15
1 ml, concentrate 441R-16
1 ml, predilute 441R-17
7 ml, predilute 441R-18
25 ml, predilute 441R-10

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 441R-14
0.5 ml, concentrate 441R-15
1 ml, concentrate 441R-16
1 ml, predilute 441R-17
7 ml, predilute 441R-18
25 ml, predilute 441R-10

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 441R-14
0.5 ml, concentrate 441R-15
1 ml, concentrate 441R-16
1 ml, predilute 441R-17
7 ml, predilute 441R-18
25 ml, predilute 441R-10

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 441R-14 (RUO)
0.5 ml, concentrate 441R-15 (RUO)
1 ml, concentrate 441R-16 (RUO)
1 ml, predilute 441R-17 (RUO)
7 ml, predilute 441R-18 (RUO)
25 ml, predilute 441R-10 (RUO)

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: prostate adenocarcinoma, prostate
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10minAb/HiDef/Perm Red

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

Download SDS

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