Mesothelin (EP140) Rabbit Monoclonal Antibody

Mesothelin
Mesothelioma is labeled in a cytoplasmic pattern by mesothelin.

Mesothelin (EP140) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology Cytopathology Pulmonary Pathology

Updated: 2017-05-24 08:46:09

Mesothelin is a 40 kDa glycosyl-phosphatudylinositol-anchored glycoprotein cleaved from a 71kDa precursor protein encoded by the human mesothelin gene. Mesothelin is present on the surface of normal mesothelial cells.1 Although the function of mesothelin is unknown, it is overexpressed in a wide variety of cancers including mesothelioma, pancreatic ductal adenocarcinoma, and ovarian carcinoma.1-6 Mesothelin has proven to be a valuable marker for pancreatic ductal adenocarcinoma due to its strong reactivity in tumor tissue and absence in normal pancreas.1, 3-4 Metastatic renal cell carcinoma can present clinical patterns that mimic primary mesothelioma, pancreatic ductal adenocarcinoma, and ovarian carcinoma.2, 4-6 Mesothelin has demonstrated utility in the differential diagnosis between these primary tumors and corresponding metastatic renal cell carcinoma within the context of an antibody panel.4-6 

  1. Hassan R, et al. Mesothelin targeted cancer immunotherapy. Eur J Cancer. 2008; 44:46-53
  2. Ordóñez NG. Value of mesothelin immunostaining in the diagnosis of mesothelioma. Mod Pathol. 2003; 16:192-7.
  3. Hassan R, et al. Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis. Am J clin Pathol. 2005; 124:838-45.
  4. Gnemmi V, et al. Pancreatic metastases of renal clear cell carcinoma: a clinicopathological study of 11 cases with special emphasis on the usefulness of PAX2 and mesothelin for the distinction from primary ductal adenocarcinoma of the pancreas. Anal Quant Cytopathol Histopathol. 2013; 35:157-62.
  5. Ordóñez NG. The diagnostic utility of immunohistochemistry in distinguishing between mesothelioma and renal cell carcinoma: a comparative study. Hum Pathol. 2004; 35:697-710.
  6. Leroy X, et al. Diagnostic value of cytokeratin 7, CD10 and mesothelin in distinguishing ovarian clear cell carcinoma from metastasis of renal clear cell carcinoma. Histopathology. 2007; 51:874-6.

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: mesothelioma, ovarian carcinoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate439R-14
0.5 mL concentrate439R-15
1 mL concentrate439R-16
1 mL predilute439R-17
7 mL predilute439R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate439R-14
0.5 mL concentrate439R-15
1 mL concentrate439R-16
1 mL predilute439R-17
7 mL predilute439R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate439R-14
0.5 mL concentrate439R-15
1 mL concentrate439R-16
1 mL predilute439R-17
7 mL predilute439R-18

For research use only (RUO) in Japan

0.1 mL concentrate439R-14-RUO
0.5 mL concentrate439R-15-RUO
1 mL concentrate439R-16-RUO
1 mL predilute439R-17-RUO
7 mL predilute439R-18-RUO

 

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