CD138 (EP201) Rabbit Monoclonal Antibody
Specialties: Hematopathology
CD138, Syndecan 1, is expressed in the late stages of B-cell differentiation with progression towards plasma cells.1,2 It can be used to differentiate lymphoplasmacytic lymphoma from marginal zone lymphoma.1 ALK+ large B-cell lyphoma (LBCL) usually strongly expresses CD138 whereas lineage-associated markers such as anti-CD20 and anti-CD79a do not stain ALK+LBCL.3,7 Anti-CD138 is immunoreactive with HHV8-associated primary effusion lymphoma even though the lymphoma cells lack the expression of B-cell markers.5 Anti-CD138 is a good marker to identify and enumerate plasma cells, benign, reactive, or malignant, in bone marrow biopsy specimens.4,6 CD138 is also expressed in epithelial cells.6
- Chilosi M, et al. CD138/syndecan-1: a useful immunohistochemical marker of normal and neoplastic plasma cells on routine trephine bone marrow biopsies. Mod Pathol. 1999; 12:1101-6.
- Sebestyén A, et al. Syndecan-1 (CD138) expression in human non-Hodgkin lymphomas. Br J Haematol. 1999; 104:412-9.
- The International Agency for Research on Cancer. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th Edition. Geneva: WHO Press. 2008. p 254.
- Bayer-Garner IB, et al. Syndecan-1 (CD138) immunoreactivity in bone marrow biopsies of multiple myeloma: shed syndecan-1 accumulates in fibrotic regions. Mod Pathol. 2001; 14:1052-8.
- The International Agency for Research on Cancer. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th Edition. Geneva: WHO Press. 2008. p 261.
- O’Connell FP, et al. CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms. Am J Clin Pathol. 2004; 121:254-63.
- Colomo L, et al. Diffuse large B-cell lymphomas with plasmablastic differentiation represent a heterogeneous group of disease entities. Am J Surg Pathol. 2004; 28:736-47.
Specifications
- Reactivity: paraffin
- Visualization: membranous
- Control: tonsil
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 2.0 (CMC13832020)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 138R-24 |
| 0.5 mL concentrate | 138R-25 |
| 1 mL concentrate | 138R-26 |
| 1 mL predilute | 138R-27 |
| 7 mL predilute | 138R-28 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 138R-24 |
| 0.5 mL concentrate | 138R-25 |
| 1 mL concentrate | 138R-26 |
| 1 mL predilute | 138R-27 |
| 7 mL predilute | 138R-28 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 138R-24 |
| 0.5 mL concentrate | 138R-25 |
| 1 mL concentrate | 138R-26 |
| 1 mL predilute | 138R-27 |
| 7 mL predilute | 138R-28 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 138R-24-RUO |
| 0.5 mL concentrate | 138R-25-RUO |
| 1 mL concentrate | 138R-26-RUO |
| 1 mL predilute | 138R-27-RUO |
| 7 mL predilute | 138R-28-RUO |
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