CD138 (EP201) Rabbit Monoclonal Antibody

CD138
CD138 (EP201) on plasma cell myeloma.

CD138 (EP201) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

CD138, Syndecan 1, is expressed in the late stages of B-cell differentiation with progression towards plasma cells.1,2 It can be used to differentiate lymphoplasmacytic lymphoma from marginal zone lymphoma.1 ALK+ large B-cell lyphoma (LBCL) usually strongly expresses CD138 whereas lineage-associated markers such as anti-CD20 and anti-CD79a do not stain ALK+LBCL.3,7 Anti-CD138 is immunoreactive with HHV8-associated primary effusion lymphoma even though the lymphoma cells lack the expression of B-cell markers.5 Anti-CD138 is a good marker to identify and enumerate plasma cells, benign, reactive, or malignant, in bone marrow biopsy specimens.4,6 CD138 is also expressed in epithelial cells.6

  1. Chilosi M, et al. CD138/syndecan-1: a useful immunohistochemical marker of normal and neoplastic plasma cells on routine trephine bone marrow biopsies. Mod Pathol. 1999; 12:1101-6.
  2. Sebestyén A, et al. Syndecan-1 (CD138) expression in human non-Hodgkin lymphomas. Br J Haematol. 1999; 104:412-9.
  3. The International Agency for Research on Cancer. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th Edition. Geneva: WHO Press. 2008. p 254.
  4. Bayer-Garner IB, et al. Syndecan-1 (CD138) immunoreactivity in bone marrow biopsies of multiple myeloma: shed syndecan-1 accumulates in fibrotic regions. Mod Pathol. 2001; 14:1052-8.
  5. The International Agency for Research on Cancer. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th Edition. Geneva: WHO Press. 2008. p 261.
  6. O’Connell FP, et al. CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms. Am J Clin Pathol. 2004; 121:254-63.
  7. Colomo L, et al. Diffuse large B-cell lymphomas with plasmablastic differentiation represent a heterogeneous group of disease entities. Am J Surg Pathol. 2004; 28:736-47.

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: tonsil
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate138R-24
0.5 mL concentrate138R-25
1 mL concentrate138R-26
1 mL predilute138R-27
7 mL predilute138R-28

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate138R-24
0.5 mL concentrate138R-25
1 mL concentrate138R-26
1 mL predilute138R-27
7 mL predilute138R-28

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate138R-24
0.5 mL concentrate138R-25
1 mL concentrate138R-26
1 mL predilute138R-27
7 mL predilute138R-28

For research use only (RUO) in Japan

0.1 mL concentrate138R-24-RUO
0.5 mL concentrate138R-25-RUO
1 mL concentrate138R-26-RUO
1 mL predilute138R-27-RUO
7 mL predilute138R-28-RUO

 

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