Islet-1 (EP283) Rabbit Monoclonal Antibody

Islet-1
Islet-1 (EP283) on medullary thyroid carcinoma.

Islet-1 (EP283) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology Gastrointestinal (GI) Pathology

Updated: 2017-05-24 08:46:09

Islet-1, a human insulin gene enhancer-binding protein, is a transcription factor involved in the differentiation of the neuroendocrine pancreatic cells.1-3 Islet-1 plays an important role in the embryogenesis and differentiation of the insulin producing pancreatic beta cells within the islets of Langerhans.3 Neuroendocrine tumors can arise from a variety of primary sites, most commonly in the bronchopulmonary system, gastrointestinal (GI) tract, and pancreas.2 Neuroendocrine tumors of the GI tract and pancreas tend to be slow growing and indolent, and may metastasize to the liver before it is detected.2 Islet-1 exhibits strong nuclear staining in the islets of normal pancreas and tumor cells of the pancreatic neuroendocrine tumor.1-3 Islet-1 has been shown to be a reliable marker for the detection of primary and metastatic pancreatic neuroendocrine neoplasms.1-3

  1. Schmitt A, et al. Islet 1 (Isl1) Expression is a reliable marker for pancreatic endocrine tumors and their metastases. Am J Surg Pathol. 2008; 32:420-425.
  2. Koo J, et al. Value of Islet 1 and PAX8 in identifying metastatic neuroendocrine tumors of pancreatic origin. Modern Pathology. 2012; 25:893-901.
  3. Agaimy A, et al. ISL1 expression is not restricted to pancreatic well-differentiated neuroendocrine neoplasms, but is also commonly found in well and poorly differentiated neuroendocrine neoplasms of extrapancreatic origin. Modern Pathology. 2013; 1-9.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: pancreas
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate431R-14
0.5 mL concentrate431R-15
1 mL concentrate431R-16
1 mL predilute431R-17
7 mL predilute431R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate431R-14
0.5 mL concentrate431R-15
1 mL concentrate431R-16
1 mL predilute431R-17
7 mL predilute431R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate431R-14
0.5 mL concentrate431R-15
1 mL concentrate431R-16
1 mL predilute431R-17
7 mL predilute431R-18

For research use only (RUO) in Japan

0.1 mL concentrate431R-14-RUO
0.5 mL concentrate431R-15-RUO
1 mL concentrate431R-16-RUO
1 mL predilute431R-17-RUO
7 mL predilute431R-18-RUO

 

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