Transgelin (2A10C2) Mouse Monoclonal Antibody

Transgelin
Transgelin antibody labels smooth muscle elements such as in the leiomyosarcoma.

Transgelin (2A10C2) Mouse Monoclonal Antibody

Specialties: Soft Tissue Pathology

Updated: 2017-05-24 08:46:09

Transgelin is a shape change sensitive 22-25 kDa actin cross-linking/gelling protein of the calponin family localized to the cell membrane and cytoplasm as a novel regulator of MMP-9 expression.1 Recent evidence suggests that transgelin may act as a tumor suppressor; for example, expression can be lost in prostate, breast and colon cancers which is consistent with suppression of the metallo matrix protease-9 (MMP-9)by transgelin, whereas MMP-9 is upregulated in these common cancers.1 This protein is ubiquitous to vascular and visceral smooth muscle and is considered an early marker of smooth muscle differentiation and may be an early and sensitive marker for the onset of transformation.2 Transgelin can be found in fibroblasts, smooth muscle and some epithelium where expression is likely driven by TGF-beta1. 3  In some cases differentiating smooth muscle within malignant lesions can be challenging, therefore use of myogenic markers such as transgelin may serve to define smooth muscle differentiation in soft tissue tumors.1-3

  1. Assinder SJ, et al. Int. Journal of Biochemistry and Cell Biology. 2009; 41:482-486.
  2. Robin YM, et al. Modern Pathology. 2013; 4:502-10.
  3. Pérot G, et al. Modern Pathology. 2014; 6:840-850.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: leiomyoma, smooth muscle tumors
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate423M-14
0.5 mL concentrate423M-15
1 mL concentrate423M-16
1 mL predilute423M-17
7 mL predilute423M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate423M-14
0.5 mL concentrate423M-15
1 mL concentrate423M-16
1 mL predilute423M-17
7 mL predilute423M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate423M-14
0.5 mL concentrate423M-15
1 mL concentrate423M-16
1 mL predilute423M-17
7 mL predilute423M-18

For research use only (RUO) in Japan

0.1 mL concentrate423M-14-RUO
0.5 mL concentrate423M-15-RUO
1 mL concentrate423M-16-RUO
1 mL predilute423M-17-RUO
7 mL predilute423M-18-RUO

 

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