Cytokeratin 17 (EP98) Rabbit Monoclonal Antibody

Cytokeratin 17
Cytokeratin 17 (EP98) on cervical intraepithelial neoplasia III.

Cytokeratin 17 (EP98) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Cytokeratin 17 is 46 kD intermediate filament found in simple epithelia and is a marker for cervical reserve (stem) cells.1,2 CK17 can be useful in the identification of uterine cervical squamous lesions including atypical immature metaplasia, cervical intraepithelial neoplasia, and cervical squamous carcinoma.1-3 CK17 also assists in the differentiation of oral squamous cell carcinoma.4

  1. Regauer S, et al. CK17 and p16 expression patterns distinguish (atypical) immature squamous metaplasia from high-grade cervical intraepithelial neoplasia (CIN III). Histopathology. 2007; 50:629-35.
  2. Martens JE, et al. Cytokeratin 17 and p63 are markers of the HPV target cell, the cervical stem cell. Anticancer Res. 2004; 24:771-5.
  3. Escobar-Hoyos LF, et al. Keratin 17 in premalignant and malignant squamous lesions of the cervix: proteomic discovery and immunohistochemical validation as a diagnostic and prognostic biomarker. Mod Pathol. 2014; 27:621-30.
  4. Kitamura R. et al. Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2012; 138:1299-1310.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: cervix immature metaplasia, breast
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate317R-14
0.5 mL concentrate317R-15
1 mL concentrate317R-16
1 mL predilute317R-17
7 mL predilute317R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate317R-14
0.5 mL concentrate317R-15
1 mL concentrate317R-16
1 mL predilute317R-17
7 mL predilute317R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate317R-14
0.5 mL concentrate317R-15
1 mL concentrate317R-16
1 mL predilute317R-17
7 mL predilute317R-18

For research use only (RUO) in Japan

0.1 mL concentrate317R-14-RUO
0.5 mL concentrate317R-15-RUO
1 mL concentrate317R-16-RUO
1 mL predilute317R-17-RUO
7 mL predilute317R-18-RUO

 

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