Claudin 7 (5D10F3) Mouse Monoclonal Antibody

Claudin 7
Claudin 7 (5D10F3) on kidney.

Claudin 7 (5D10F3) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Claudin-7 is a transmembrane protein involved in the formation of tight junctions between epithelial cells.1 The Claudin family of proteins are involved in critical roles of cellular polarity, signal transductions, and have been implicated in the pathogenesis of various human neoplasms including chromophobe renal cell carcinoma. The identification between chromophobe renal cell carcinoma and oncocytoma is difficult by light microscopy, and yet important as chromophobe renal cell carcinoma is malignant, whereas oncocytoma is benign.2 Anti-claudin-7 reactivity is seen in most chromophobe renal cell carcinomas, while it is rarely seen in oncocytomas, and only seen in a minority of clear cell renal cell carcinomas.1,3 Therefore, anti-claudin-7 could be a useful immunohistochemical marker for the distinction and identification of chromophobe renal cell carcinoma.

  1. Li L, et al. Expression of Claudin-7 in Benign Kidney and Kidney Tumors. International Journal of Clinical and Experimental Pathology. 2008; 1:57-64.
  2. Hornsby CD, et al. Claudin-7 Immunohistochemistry in Renal Tumors: A Candidate Marker for Chromophobe Renal Cell Carcinoma Identified by Gene Expression Profiling. Archives of Pathology and Laboratory Medicine. 2007; 10:1541-6.
  3. Choi YD, et al. Claudin-7 is Highly Expressed In Chromophobe Renal Cell Carcinoma and Renal Oncocytoma. Journal of Korean Medical Science. 2007; 2:305-10.
  4. Osunkoya AO, et al. Claudin-7 and Claudin-8: Immunohistochemical Markers for the Differential Diagnosis of Chromophobe Renal Cell Carcinoma and Renal Oncocytoma. Human Patholology. 2009; 2:206-10.

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: chromophobe renal cell carcinoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate418M-14
0.5 mL concentrate418M-15
1 mL concentrate418M-16
1 mL predilute418M-17
7 mL predilute418M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate418M-14
0.5 mL concentrate418M-15
1 mL concentrate418M-16
1 mL predilute418M-17
7 mL predilute418M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate418M-14
0.5 mL concentrate418M-15
1 mL concentrate418M-16
1 mL predilute418M-17
7 mL predilute418M-18

For research use only (RUO) in Japan

0.1 mL concentrate418M-14-RUO
0.5 mL concentrate418M-15-RUO
1 mL concentrate418M-16-RUO
1 mL predilute418M-17-RUO
7 mL predilute418M-18-RUO

 

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