CD123 (6H6) Mouse Monoclonal Antibody

CD123
CD123 monoclonal antibody stains a cytoplasmic/membranous pattern for blastic plasmacytoid dendritic cell neoplasm.

CD123 (6H6) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

Blastic plasmacytoid dendritic cell neoplasm (BPDCN), previously known as CD4+/CD56+ hematodermic neoplasm or blastic NK-cell lymphoma, is a malignant neoplasm composed of immature hematopoietic precursors of plasmacytoid dendritic cells.1 The most frequent manifestation is a skin lesion, bone marrow involvement, and regional lymphadenopathy.1 Myeloid leukemia cutis (LC), myeloid sarcoma, and large aggressive B cell lymphomas should be differentiated from BPDCN. Recently, it has been reported that these entities can be distinguished by using immunohistochemistry (IHC) in paraffin-embedded tissue sections.2 CD123 is able to distinguish BPDCN from diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, hairy cell leukemia, and small lymphocytic lymphoma.

  1. Facchetti F, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: IARC Press; 2008:145-7.
  2. Cronin DMP, et al. Immunophenotypic analysis of myeloperoxidase-negative leukemia cutis and blastic plasmacytoid dendritic cell neoplasm. Am J Clin Pathol. 2012; 137:367-76.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: blastic plasmacytoid dendritic cell neoplasm
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate198M-14
0.5 mL concentrate198M-15
1 mL concentrate198M-16
1 mL predilute198M-17
7 mL predilute198M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate198M-14
0.5 mL concentrate198M-15
1 mL concentrate198M-16
1 mL predilute198M-17
7 mL predilute198M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate198M-14
0.5 mL concentrate198M-15
1 mL concentrate198M-16
1 mL predilute198M-17
7 mL predilute198M-18

For research use only (RUO) in Japan

0.1 mL concentrate198M-14-RUO
0.5 mL concentrate198M-15-RUO
1 mL concentrate198M-16-RUO
1 mL predilute198M-17-RUO
7 mL predilute198M-18-RUO

 

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