Cell Marque Portfolio

CD123 (6H6)

Mouse Monoclonal


Blastic plasmacytoid dendritic cell neoplasm (BPDCN), previously known as CD4+/CD56+ hematodermic neoplasm or blastic NK-cell lymphoma, is a malignant neoplasm composed of immature hematopoietic precursors of plasmacytoid dendritic cells.1 The most frequent manifestation is a skin lesion, bone marrow involvement, and regional lymphadenopathy.1 Myeloid leukemia cutis (LC), myeloid sarcoma, and large aggressive B cell lymphomas should be differentiated from BPDCN. Recently, it has been reported that these entities can be distinguished by using immunohistochemistry (IHC) in paraffin-embedded tissue sections.2 CD123 is able to distinguish BPDCN from diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, hairy cell leukemia, and small lymphocytic lymphoma.

Specialties: Hematopathology

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: blastic plasmacytoid dendritic cell neoplasm
  • Isotype: IgG1/k
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

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Keycode Specific IFU

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References


  1. Facchetti F, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: IARC Press; 2008:145-7.
  2. Cronin DMP, et al. Immunophenotypic analysis of myeloperoxidase-negative leukemia cutis and blastic plasmacytoid dendritic cell neoplasm. Am J Clin Pathol. 2012; 137:367-76.

Last updated: 2017-05-24 08:46:09

CD123
CD123 monoclonal antibody stains a cytoplasmic/membranous pattern for blastic plasmacytoid dendritic cell neoplasm.

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Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: blastic plasmacytoid dendritic cell neoplasm
  • Isotype: IgG1/k
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

References


  1. Facchetti F, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: IARC Press; 2008:145-7.
  2. Cronin DMP, et al. Immunophenotypic analysis of myeloperoxidase-negative leukemia cutis and blastic plasmacytoid dendritic cell neoplasm. Am J Clin Pathol. 2012; 137:367-76.

Download an IFU

Select revision:


Download SDS


Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 198M-14
0.5 ml, concentrate 198M-15
1 ml, concentrate 198M-16
1 ml, predilute 198M-17
7 ml, predilute 198M-18

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 198M-14
0.5 ml, concentrate 198M-15
1 ml, concentrate 198M-16
1 ml, predilute 198M-17
7 ml, predilute 198M-18

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 198M-14
0.5 ml, concentrate 198M-15
1 ml, concentrate 198M-16
1 ml, predilute 198M-17
7 ml, predilute 198M-18

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 198M-14-RUO
0.5 ml, concentrate 198M-15-RUO
1 ml, concentrate 198M-16-RUO
1 ml, predilute 198M-17-RUO
7 ml, predilute 198M-18-RUO

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: blastic plasmacytoid dendritic cell neoplasm
  • Isotype: IgG1/k
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

Download SDS

References


  1. Facchetti F, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: IARC Press; 2008:145-7.
  2. Cronin DMP, et al. Immunophenotypic analysis of myeloperoxidase-negative leukemia cutis and blastic plasmacytoid dendritic cell neoplasm. Am J Clin Pathol. 2012; 137:367-76.
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