Calcitonin Rabbit Polyclonal Antibody
Specialties: Cytopathology Head/Neck Pathology
Calcitonin (thyrocalcitonin) is a 32 amino acid linear polypeptide hormone that is involved in regulating calcium metabolism.1 It is primarily produced by the parafollicular cells (also known as C cells) of the thyroid gland, though some neuroendocrine cells in other tissues, such as the respiratory and digestive tracts, can also synthesize calcitonin.1,2 Anti-calcitonin immunohistochemistry is an effective way for demonstrating the parafollicular C cells in the thyroid3,4 and the tumors arising from them, including C cell hyperplasia of the thyroid and medullary thyroid carcinoma, a neuroendocrine tumor that originates from C cells.3
- Barrett EJ. The thyroid gland. In: Boron WF, Boulpaep EL, eds. Medical Physiology. A Cellular and Molecular Approach. Updated Second Edition. Philadelphia, PA: Saunders Elsevier; 2012: 1974-1998.
- Tsutsumi, Y. "Immunohistochemical analysis of calcitonin and calcitonin gene-related peptide in human lung." Human pathology vol. 20,9 (1989): 896-902.
- Matias-Guiu, Xavier, and Ronald De Lellis. "Medullary thyroid carcinoma: a 25-year perspective." Endocrine pathology vol. 25,1 (2014): 21-9.
- Fischer, Sandra, and Sylvia L Asa. "Application of immunohistochemistry to thyroid neoplasms." Archives of pathology & laboratory medicine vol. 132,3 (2008): 359-72.
Specifications
- Reactivity: paraffin
- Control: Thyroid Medullary Carcinoma (Cytoplasmic)
- Dilution Range: 1:200-1:1000 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC22911050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 229A-14 |
| 0.5 mL concentrate | 229A-15 |
| 1.0 mL concentrate | 229A-16 |
| 1.0 mL predilute ready-to-use | 229A-17 |
| 7.0 mL predilute ready-to-use | 229A-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 229A-14 |
| 0.5 mL concentrate | 229A-15 |
| 1.0 mL concentrate | 229A-16 |
| 1.0 mL predilute ready-to-use | 229A-17 |
| 7.0 mL predilute ready-to-use | 229A-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 229A-14 |
| 0.5 mL concentrate | 229A-15 |
| 1.0 mL concentrate | 229A-16 |
| 1.0 mL predilute ready-to-use | 229A-17 |
| 7.0 mL predilute ready-to-use | 229A-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 229A-14-RUO |
| 0.5 mL concentrate (RUO) | 229A-15-RUO |
| 1.0 mL concentrate (RUO) | 229A-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 229A-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 229A-18-RUO |
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