FSH (EP257) Rabbit Monoclonal Antibody

FSH
FSH (EP257) on pituitary.

FSH (EP257) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology Neuropathology

Updated: 2017-05-24 08:46:09

Follicle-stimulating hormone (FSH) is a member of the pituitary glycoprotein hormone family which also includes luteinizing hormone (LH), chorionic gonadotropin (hCG), and thyroid-stimulating hormone (TSH).1 Members of the pituitary glycoprotein hormone family consist of a shared alpha chain and a beta chain encoded by a separate gene.1-3 The FSHB gene encodes the beta subunit of follicle stimulating hormone.1-3 FSH enables ovarian folliculogenesis and is essential for Sertoli cell proliferation and spermatogenesis.2 Anti-FSH is a useful marker in classification of pituitary neoplasms because it labels FSH-producing cells (gonadotrophs).3-5

  1. Baenziger JU, et al. Pituitary glycoprotein hormone oligosaccharides: Structure, synthesis and function of the asparagine-linked oligosaccharides on lutropin, follitropin and thyrotropin. Biochim Biophys Acta. 1988; 947:287-306.
  2. Nussey SS, et al. Endocrinology: An integrated approach. BIOS Scientific Publishers Ltd; 2001 p. 217-79.
  3. Uccella S, et al. Localization of inhibin/activin subunits in normal pituitary and in pituitary adenomas. Pituitary. 2000; 3:131-9.
  4. Schmid M, et al. Pituitary hormone mRNA in null cell adenomas and oncocytomas by in situ hybridization comparison with immunohistochemical and clinical data. Pathol Res Pract. 2001; 197:663-9.
  5. La Rosa S, et al. Detection of gonadotropin-releasing hormone receptor in normal human pituitary cells and pituitary adenomas using immunohistochemistry. Virchows Arch. 2000; 437:264-9.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: pituitary
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate207R-14
0.5 mL concentrate207R-15
1 mL concentrate207R-16
1 mL predilute207R-17
7 mL predilute207R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate207R-14
0.5 mL concentrate207R-15
1 mL concentrate207R-16
1 mL predilute207R-17
7 mL predilute207R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate207R-14
0.5 mL concentrate207R-15
1 mL concentrate207R-16
1 mL predilute207R-17
7 mL predilute207R-18

For research use only (RUO) in Japan

0.1 mL concentrate207R-14-RUO
0.5 mL concentrate207R-15-RUO
1 mL concentrate207R-16-RUO
1 mL predilute207R-17-RUO
7 mL predilute207R-18-RUO

 

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