Desmin (EP15) Rabbit Monoclonal Antibody

Desmin
Rabbit monoclonal anti-desmin shows a strong, diffuse, and cytoplasmic expression of the desmin protein in rhabdomyosarcoma.

Desmin (EP15) Rabbit Monoclonal Antibody

Specialties: Soft Tissue Pathology

Updated: 2017-05-24 08:46:09

Anti-desmin detects a protein that is expressed by cells of normal smooth, skeletal, and cardiac muscles. It has been suggested that desmin is primarily located at or near the periphery of Z lines in striated muscle fibrils. In smooth muscle, desmin interconnects cytoplasmic dense bodies with membrane bound dense plaques. Anti-desmin reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin. This antibody is used to demonstrate the myogenic components/derivation of tumors.1,2 Desmin can also be present in myofibroblasts and be focally positive in desmoid fibromatosis.3

  1. Altmannsberger M, et al. Am J Pathol 1985; 118:85-95.
  2. Debus E, et al. EMBO J. 1983; 2:2305-2312.
  3. Yamaguchi U, et al. Virchows Arch. 2004; 2:142-50.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: skeletal muscle
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate243R-14
0.5 mL concentrate243R-15
1 mL concentrate243R-16
1 mL predilute243R-17
7 mL predilute243R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate243R-14
0.5 mL concentrate243R-15
1 mL concentrate243R-16
1 mL predilute243R-17
7 mL predilute243R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate243R-14
0.5 mL concentrate243R-15
1 mL concentrate243R-16
1 mL predilute243R-17
7 mL predilute243R-18

For research use only (RUO) in Japan

0.1 mL concentrate243R-14-RUO
0.5 mL concentrate243R-15-RUO
1 mL concentrate243R-16-RUO
1 mL predilute243R-17-RUO
7 mL predilute243R-18-RUO

 

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