ERG (EP111) Rabbit Monoclonal Antibody

ERG
Prostatic acinar carcinoma is stained positive by ERG antibody in a nuclear pattern. Note on the right low grade prostate intraepithelial neoplasia is completely negative for ERG.

ERG (EP111) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology Genitourinary (GU) Pathology

Updated: 2017-05-24 08:46:09

The transcription factor erythroblastosis virus E26 transforming sequence related gene (ERG) functions as a regulator of key cellular functions to promote endothelial homeostasis.1 Expression of ERG has been observed in both benign and malignant vascular endothelial tumors, such as hemangiomas and Kaposi sarcomas, respectively.2,3 Carcinomas of the breast, colon, and urothelium have demonstrated absence of ERG expression, whereas presence of the protein has been confirmed in a subset of prostate carcinoma cases.4,5 Anti-ERG can be a useful tool for identifying vascular endothelial neoplasms and distinguishing prostate carcinoma from epithelial tumors of non-prostatic origin.

  1. Shah AV, et al. Vascul Pharmacol. 2016; 86:3-13.
  2. Miettinen M, et al. Am J Surg Pathol. 2011; 35:432-441.
  3. Minner S, et al. Modpathol. 2013; 26:106-116.
  4. Hornick JL. Modern Pathology. 2014; 27:S47-S63.
  5. Tomlins SA, et al. Am J Clin Pathol. 2013; 139:771-779.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: hemangioma, tonsil
  • Dilution Range: 1:100-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute434R-10
0.1 mL concentrate434R-14
0.5 mL concentrate434R-15
1 mL concentrate434R-16
1 mL predilute434R-17
7 mL predilute434R-18

For in vitro diagnostic (IVD) use in Canada

25 mL predilute434R-10
0.1 mL concentrate434R-14
0.5 mL concentrate434R-15
1 mL concentrate434R-16
1 mL predilute434R-17
7 mL predilute434R-18

For in vitro diagnostic (IVD) use in Europe

25 mL predilute434R-10
0.1 mL concentrate434R-14
0.5 mL concentrate434R-15
1 mL concentrate434R-16
1 mL predilute434R-17
7 mL predilute434R-18

For research use only (RUO) in Japan

25 mL predilute434R-10-RUO
0.1 mL concentrate434R-14-RUO
0.5 mL concentrate434R-15-RUO
1 mL concentrate434R-16-RUO
1 mL predilute434R-17-RUO
7 mL predilute434R-18-RUO

 

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