Cell Marque Portfolio

ERG (EP111)

Rabbit Monoclonal


ERG is a member of the erythroblastosis virus E26 transforming sequence (ETS) transcription factor gene family, which also includes Fli-1 and ETS-1.1-5 ERG is expressed in lymphocytes and endothelial cells and regulates endothelial apoptosis and angiogenesis. ERG has been found to be expressed in both benign and malignant vascular tumors. Anti-ERG was found to have high sensitivity for vascular neoplasms.1 ERG expression has been observed in prostate carcinomas and high-grade prostatic intraepithelial neoplasia (HGPIN).1-4 ERG positivity in any other epithelial tumor other than prostate carcinoma is extremely rare. In a study of all carcinomas of the breast, gastrointestinal tract, gynecologic system, kidney, lung, ovary, pancreas, salivary glands, skin, thyroid, and testis were negative for ERG.1 ERG has also been observed to be positive in a minority of Ewing sarcomas.2 This is caused by a chromosomal rearrangement which fuses the EWSR1 gene with the ERG gene (EWSR 1:ERG).5 ERG has also been observed to stain some meningiomas due to cross reactivity with Fli-1.1

Specialties: Anatomic Pathology Genitourinary (GU) Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: hemangioma, tonsil
  • Isotype: IgG
  • Dilution Range: 1:100-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10minAb/HiDef/Perm Red
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

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Last updated: 2016-09-29 13:18:40

ERG
Prostatic acinar carcinoma is stained positive by ERG antibody in a nuclear pattern. Note on the right low grade prostate intraepithelial neoplasia is completely negative for ERG.

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Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: hemangioma, tonsil
  • Isotype: IgG
  • Dilution Range: 1:100-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10minAb/HiDef/Perm Red
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Download an IFU

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 434R-14
0.5 ml, concentrate 434R-15
1 ml, concentrate 434R-16
1 ml, predilute 434R-17
7 ml, predilute 434R-18
25 ml, predilute 434R-10

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 434R-14
0.5 ml, concentrate 434R-15
1 ml, concentrate 434R-16
1 ml, predilute 434R-17
7 ml, predilute 434R-18
25 ml, predilute 434R-10

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 434R-14
0.5 ml, concentrate 434R-15
1 ml, concentrate 434R-16
1 ml, predilute 434R-17
7 ml, predilute 434R-18
25 ml, predilute 434R-10

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 434R-14 (RUO)
0.5 ml, concentrate 434R-15 (RUO)
1 ml, concentrate 434R-16 (RUO)
1 ml, predilute 434R-17 (RUO)
7 ml, predilute 434R-18 (RUO)
25 ml, predilute 434R-10 (RUO)

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: hemangioma, tonsil
  • Isotype: IgG
  • Dilution Range: 1:100-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/10minAb/HiDef/Perm Red
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

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