S100A1 (EP184) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology
S100 Calcium Binding Protein A1 or S100A1 is in a family of proteins which contain 2 EF-hand calcium binding motifs.1 S100 proteins are expressed in a wide range of cells, and localized in the cytoplasm and/or nucleus. Anti-S100A1 reactivity is seen in normal renal tissue, proximal tubules, loops of Henle, collecting ducts, skeletal muscle, and dendritic cells of lymph nodes of normal tissues. In immunohistochemistry anti-S100A1 is reportedly useful in differentiating renal oncocytoma from chromophobe renal cell carcinoma.2,3
- Zimmer DA, et al. The S100 protein family: history, function, and expression. Brain Res Bull. 1995; 37:417-29.
- Rocca PC, et al. Diagnostic utility of S100A1 expression in renal cell neoplasms: an immunohistochemical and quantitative RT-PCR study. Mod Pathol. 2007; 20:722-8.
- Li G, et al. S100A1: a powerful marker to differentiate chromophobe renal cell carcinoma from renal oncocytoma. Histopathology. 2007; 50:642-7.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic, nuclear
- Control: renal oncocytoma, kidney
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 3.0 (CMC40831030)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 408R-14 |
| 0.5 mL concentrate | 408R-15 |
| 1 mL concentrate | 408R-16 |
| 1 mL predilute | 408R-17 |
| 7 mL predilute | 408R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 408R-14 |
| 0.5 mL concentrate | 408R-15 |
| 1 mL concentrate | 408R-16 |
| 1 mL predilute | 408R-17 |
| 7 mL predilute | 408R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 408R-14 |
| 0.5 mL concentrate | 408R-15 |
| 1 mL concentrate | 408R-16 |
| 1 mL predilute | 408R-17 |
| 7 mL predilute | 408R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 408R-14-RUO |
| 0.5 mL concentrate | 408R-15-RUO |
| 1 mL concentrate | 408R-16-RUO |
| 1 mL predilute | 408R-17-RUO |
| 7 mL predilute | 408R-18-RUO |
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