Cell Marque Portfolio

S100A1 (EP184)

Rabbit Monoclonal


S100 Calcium Binding Protein A1 or S100A1 is in a family of proteins which contain 2 EF-hand calcium binding motifs.1 S100 proteins are expressed in a wide range of cells, and localized in the cytoplasm and/or nucleus. Anti-S100A1 reactivity is seen in normal renal tissue, proximal tubules, loops of Henle, collecting ducts, skeletal muscle, and dendritic cells of lymph nodes of normal tissues. In immunohistochemistry anti-S100A1 is reportedly useful in differentiating renal oncocytoma from chromophobe renal cell carcinoma.2,3

Specialties: Anatomic Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, nuclear
  • Control: renal oncocytoma, kidney
  • Isotype: IgG
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C + AMP

References


  1. Zimmer DA, et al. The S100 protein family: history, function, and expression. Brain Res Bull. 1995; 37:417-29.
  2. Rocca PC, et al. Diagnostic utility of S100A1 expression in renal cell neoplasms: an immunohistochemical and quantitative RT-PCR study. Mod Pathol. 2007; 20:722-8.
  3. Li G, et al. S100A1: a powerful marker to differentiate chromophobe renal cell carcinoma from renal oncocytoma. Histopathology. 2007; 50:642-7.

Literature

Last updated: 2017-05-24 08:46:09

S100A1
Renal oncocytoma tumor cells are labelled by anti-S100A1 in a cytoplasmic and nuclear pattern.

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Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, nuclear
  • Control: renal oncocytoma, kidney
  • Isotype: IgG
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C + AMP

References


  1. Zimmer DA, et al. The S100 protein family: history, function, and expression. Brain Res Bull. 1995; 37:417-29.
  2. Rocca PC, et al. Diagnostic utility of S100A1 expression in renal cell neoplasms: an immunohistochemical and quantitative RT-PCR study. Mod Pathol. 2007; 20:722-8.
  3. Li G, et al. S100A1: a powerful marker to differentiate chromophobe renal cell carcinoma from renal oncocytoma. Histopathology. 2007; 50:642-7.

Package Inserts

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Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate 408R-14
0.5 mL concentrate 408R-15
1 mL concentrate 408R-16
1 mL predilute 408R-17
7 mL predilute 408R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate 408R-14
0.5 mL concentrate 408R-15
1 mL concentrate 408R-16
1 mL predilute 408R-17
7 mL predilute 408R-18

For in vitro diagnostic (IVD) use in the EU

0.1 mL concentrate 408R-14
0.5 mL concentrate 408R-15
1 mL concentrate 408R-16
1 mL predilute 408R-17
7 mL predilute 408R-18

For research use only (RUO) in Japan

0.1 mL concentrate 408R-14-RUO
0.5 mL concentrate 408R-15-RUO
1 mL concentrate 408R-16-RUO
1 mL predilute 408R-17-RUO
7 mL predilute 408R-18-RUO

Literature

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, nuclear
  • Control: renal oncocytoma, kidney
  • Isotype: IgG
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C + AMP

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References


  1. Zimmer DA, et al. The S100 protein family: history, function, and expression. Brain Res Bull. 1995; 37:417-29.
  2. Rocca PC, et al. Diagnostic utility of S100A1 expression in renal cell neoplasms: an immunohistochemical and quantitative RT-PCR study. Mod Pathol. 2007; 20:722-8.
  3. Li G, et al. S100A1: a powerful marker to differentiate chromophobe renal cell carcinoma from renal oncocytoma. Histopathology. 2007; 50:642-7.
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