Cell Marque Portfolio

S100A1 (EP184)

Rabbit Monoclonal


S100A1 is a member of S100 protein family of calcium binding proteins.1 S100A1 is very useful in the identification of renal cell carcinoma.2-3 Published literature indicates that 93% of renal oncocytomas reacted positively by anti-S100A1. Most of them showed both cytoplasmic and nuclear immunostaining with moderate-to-strong intensity. S100A1 immunostaining was also observed in 73% of clear cell renal cell carcinomas. Anti-S100A1 detected 94% of papillary renal cell carcinomas.2 This study also demonstrated that 94% of chromophobe renal cell carcinomas showed no labeling by anti-S100A1. Therefore, anti-S100A1 is very useful in the differentiation of renal oncocytoma from chromophobe renal cell carcinoma as well as distinguishing clear cell renal cell carcinoma from chromophobe renal cell carcinoma.2 S100A1 is detected in normal renal tissue and expressed in  both the nuclei and the cytoplasm of the cells lining proximal tubules, loops of Henle, and collecting ducts. The glomerular components are negative. S100A1 is also expressed by skeletal muscle and myocardium; and specific cytoplasmic expression is found in follicular dendritic cells of lymph nodes.2

Specialties: Anatomic Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, nuclear
  • Control: renal oncocytoma, kidney
  • Isotype: IgG
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C + AMP

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Literature

S100A1
Renal oncocytoma tumor cells are labelled by anti-S100A1 in a cytoplasmic and nuclear pattern.

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Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, nuclear
  • Control: renal oncocytoma, kidney
  • Isotype: IgG
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C + AMP

Download an IFU

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 408R-14
0.5 ml, concentrate 408R-15
1 ml, concentrate 408R-16
1 ml, predilute 408R-17
7 ml, predilute 408R-18

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 408R-14
0.5 ml, concentrate 408R-15
1 ml, concentrate 408R-16
1 ml, predilute 408R-17
7 ml, predilute 408R-18

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 408R-14
0.5 ml, concentrate 408R-15
1 ml, concentrate 408R-16
1 ml, predilute 408R-17
7 ml, predilute 408R-18

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 408R-14
0.5 ml, concentrate 408R-15
1 ml, concentrate 408R-16
1 ml, predilute 408R-17
7 ml, predilute 408R-18

Literature

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, nuclear
  • Control: renal oncocytoma, kidney
  • Isotype: IgG
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C + AMP

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

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