Cell Marque Portfolio

Caveolin-1 (2297)

Mouse Monoclonal


Caveolin-1 (CAV-1) is a cell membrane-associated structural component of flask-shaped plasma membrane invaginations termed caveolae.1 CAV-1 is expressed at different levels in different tissues, with the highest in adipocytes, endothelial cells, fibroblasts, and mesothelial cells.1 Anti-CAV-1 is useful in assisting in the identification of epithelioid mesothelioma. A study by Amatya et al. indicates CAV-1 expression in all 80 (100%) epithelioid mesotheliomas, whereas only 6/80 (7.5%) of the lung adenocarcinomas were positive for CAV-1.2 Staining in most mesotheliomas was strong and diffuse when compared with the weak, focal staining (no more than 1% of the tumor cells) seen in the lung adenocarcinomas, anti-CAV-1 is considered a very useful marker for assisting in discriminating between these two malignancies. They also indicated that anti-CAV-1 is comparable to other mesothelioma markers such as anti-calretinin and anti-D2-40 (podoplanin) that are commonly used to assist in the differentiation between epithelioid mesotheliomas and lung adenocarcinomas.2 Anti-CAV-1 is also useful in identification of Ewing sarcoma/PNET. Literature indicates CAV-1 expression in 368 (96%) of 383 cases of Ewing sarcoma/PNET.3 In summary, anti-CAV-1 is very useful in the differentiation of epithelioid mesothelioma from lung adenocarcinoma and identification of Ewing sarcoma/PNET.3

Specialties: Cytopathology Pulmonary Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: mesothelioma, Ewing sarcoma
  • Isotype: IgG1
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?



*Note: IFUs with the prefix RUO or ASR are only available for download in English.


Click here to learn about keycodes

Literature

Caveolin-1
Caveolin-1 (2297) on soft tissue.

Mouse over to zoom, use scroll wheel to zoom in/out

Tap image once to activate zoom lens


Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: mesothelioma, Ewing sarcoma
  • Isotype: IgG1
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Download an IFU

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 412M-14
0.5 ml, concentrate 412M-15
1 ml, concentrate 412M-16
1 ml, predilute 412M-17
7 ml, predilute 412M-18

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 412M-14
0.5 ml, concentrate 412M-15
1 ml, concentrate 412M-16
1 ml, predilute 412M-17
7 ml, predilute 412M-18

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 412M-14
0.5 ml, concentrate 412M-15
1 ml, concentrate 412M-16
1 ml, predilute 412M-17
7 ml, predilute 412M-18

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 412M-14
0.5 ml, concentrate 412M-15
1 ml, concentrate 412M-16
1 ml, predilute 412M-17
7 ml, predilute 412M-18

Literature

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: mesothelioma, Ewing sarcoma
  • Isotype: IgG1
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

Request More Information