Cell Marque Portfolio

Caveolin-1 (2297)

Mouse Monoclonal


Caveolin-1 (CAV-1)  is a cell membrane-associated structural component of flask-shaped plasma membrane invaginations termed caveolae.1 CAV-1 is expressed at different levels in different tissues, with the highest in adipocytes, endothelial cells, fibroblasts, alveolar type I pneumocytes, and mesothelial cells.1-2 Anti-Caveolin-1 immunoreactivity is seen in the vast majority of epithelioid mesotheliomas and Ewing sarcoma/PNET, whereas reactivity in lung adenocarcinomas is only occasionally seen and in a weak and focal pattern.2-3

Specialties: Cytopathology Pulmonary Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: mesothelioma, Ewing sarcoma
  • Isotype: IgG1
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

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Keycode Specific IFU

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References


  1. Cohen AW, et al. Role of caveolae and caveolins in health and disease. Physiol Rev. 2004; 84:1341-79.
  2. Amatya VJ, et al. Caveolin-1 is a novel Immunohistochemical marker to differentiate Epithelioid Mesothelioma from Lung Adenocarcinoma. Histopathology. 2009; 55:10-9.
  3. Llombart-Bosch A, et al. Histological heterogeneity of Ewing’s sarcoma/PNET: An immunohistochemical analysis of 415 genetically confirmed cases with clinical support. Virchows Arch. 2009; 455:397-411.

Literature

Last updated: 2017-05-24 08:46:09

Caveolin-1
Caveolin-1 (2297) on soft tissue.

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Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: mesothelioma, Ewing sarcoma
  • Isotype: IgG1
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

References


  1. Cohen AW, et al. Role of caveolae and caveolins in health and disease. Physiol Rev. 2004; 84:1341-79.
  2. Amatya VJ, et al. Caveolin-1 is a novel Immunohistochemical marker to differentiate Epithelioid Mesothelioma from Lung Adenocarcinoma. Histopathology. 2009; 55:10-9.
  3. Llombart-Bosch A, et al. Histological heterogeneity of Ewing’s sarcoma/PNET: An immunohistochemical analysis of 415 genetically confirmed cases with clinical support. Virchows Arch. 2009; 455:397-411.

Download an IFU

Select revision:


Download SDS


Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 412M-14
0.5 ml, concentrate 412M-15
1 ml, concentrate 412M-16
1 ml, predilute 412M-17
7 ml, predilute 412M-18

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 412M-14
0.5 ml, concentrate 412M-15
1 ml, concentrate 412M-16
1 ml, predilute 412M-17
7 ml, predilute 412M-18

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 412M-14
0.5 ml, concentrate 412M-15
1 ml, concentrate 412M-16
1 ml, predilute 412M-17
7 ml, predilute 412M-18

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 412M-14-RUO
0.5 ml, concentrate 412M-15-RUO
1 ml, concentrate 412M-16-RUO
1 ml, predilute 412M-17-RUO
7 ml, predilute 412M-18-RUO

Literature

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: mesothelioma, Ewing sarcoma
  • Isotype: IgG1
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/16min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

Download SDS

References


  1. Cohen AW, et al. Role of caveolae and caveolins in health and disease. Physiol Rev. 2004; 84:1341-79.
  2. Amatya VJ, et al. Caveolin-1 is a novel Immunohistochemical marker to differentiate Epithelioid Mesothelioma from Lung Adenocarcinoma. Histopathology. 2009; 55:10-9.
  3. Llombart-Bosch A, et al. Histological heterogeneity of Ewing’s sarcoma/PNET: An immunohistochemical analysis of 415 genetically confirmed cases with clinical support. Virchows Arch. 2009; 455:397-411.
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