Caveolin-1 (2297) Mouse Monoclonal Antibody

Caveolin-1
Caveolin-1 (2297) on soft tissue.

Caveolin-1 (2297) Mouse Monoclonal Antibody

Specialties: Cytopathology Pulmonary Pathology

Updated: 2017-05-24 08:46:09

Caveolin-1 (CAV-1)  is a cell membrane-associated structural component of flask-shaped plasma membrane invaginations termed caveolae.1 CAV-1 is expressed at different levels in different tissues, with the highest in adipocytes, endothelial cells, fibroblasts, alveolar type I pneumocytes, and mesothelial cells.1-2 Anti-Caveolin-1 immunoreactivity is seen in the vast majority of epithelioid mesotheliomas and Ewing sarcoma/PNET, whereas reactivity in lung adenocarcinomas is only occasionally seen and in a weak and focal pattern.2-3

  1. Cohen AW, et al. Role of caveolae and caveolins in health and disease. Physiol Rev. 2004; 84:1341-79.
  2. Amatya VJ, et al. Caveolin-1 is a novel Immunohistochemical marker to differentiate Epithelioid Mesothelioma from Lung Adenocarcinoma. Histopathology. 2009; 55:10-9.
  3. Llombart-Bosch A, et al. Histological heterogeneity of Ewing’s sarcoma/PNET: An immunohistochemical analysis of 415 genetically confirmed cases with clinical support. Virchows Arch. 2009; 455:397-411.

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: mesothelioma, Ewing sarcoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate412M-14
0.5 mL concentrate412M-15
1 mL concentrate412M-16
1 mL predilute412M-17
7 mL predilute412M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate412M-14
0.5 mL concentrate412M-15
1 mL concentrate412M-16
1 mL predilute412M-17
7 mL predilute412M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate412M-14
0.5 mL concentrate412M-15
1 mL concentrate412M-16
1 mL predilute412M-17
7 mL predilute412M-18

For research use only (RUO) in Japan

0.1 mL concentrate412M-14-RUO
0.5 mL concentrate412M-15-RUO
1 mL concentrate412M-16-RUO
1 mL predilute412M-17-RUO
7 mL predilute412M-18-RUO

 

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