Heat Shock Protein 27 (G3.1) Mouse Monoclonal Antibody

Heat Shock Protein 27
High grade cervical intraepithelial neoplasia (CINIII) demonstrates strong diffuse and cytoplasmic expression of heat shock protein 27. Note the glandular component in this CINIII with glandular duct involvement is negative for HSP27.

Heat Shock Protein 27 (G3.1) Mouse Monoclonal Antibody

Specialties: Breast/Gynecological Pathology

Updated: 2017-05-24 08:46:09

Heat shock proteins (HSPs) are a family of molecular chaperones that facilitate a host of critical cellular functions, including protein homeostasis, transport processes, and signal transduction. These proteins can be detected under normal physiological conditions but there is a general increase in expression upon exposure to cellular stresses. In cancerous disease states, HSPs function in promoting tumor cell survival.Among the members of the HSP family that have been subject to extensive study, Hsp27 has been demonstrated to be present in a variety of cancer types, including malignancies of the breast,2 colon,3 kidney,4 and cervix.5  Anti-Hsp27 has also been shown to be helpful in distinguishing between high grade cervical intraepithelial neoplasms from low grade lesions.6

  1. Vahid S, et al. Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancer. Sci Rep. 2016; 6:31842.
  2. Grzegrzolka J, et al. Hsp-27 expression in invasive ductal breast carcinoma. Folia Histochem Cytobiol. 2012; 50:527-33.
  3. Yu Z, et al. Clinical significance of HSP27 expression in colorectal cancer. Mol Med Rep. 2010; 3:953-8.
  4. Erkizan O, et al. Significance of heat shock protein-27 expression in patients with renal cell carcinoma. Urology. 2004; 64:474-8.
  5. Ono A, et al. Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues. Hum Pathol. 2009; 40:41-9.
  6. Tozawa-Ono A, et al. Heat shock protein 27 and p16 immunohistochemistry in cervical intraepithelial neoplasia and squamous cell carcinoma. Hum Cell. 2012; 25:24-8.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: cervical intraepithelial neoplasm, cervical squamous cell carcinoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate398M-14
0.5 mL concentrate398M-15
1 mL concentrate398M-16
1 mL predilute398M-17
7 mL predilute398M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate398M-14
0.5 mL concentrate398M-15
1 mL concentrate398M-16
1 mL predilute398M-17
7 mL predilute398M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate398M-14
0.5 mL concentrate398M-15
1 mL concentrate398M-16
1 mL predilute398M-17
7 mL predilute398M-18

For research use only (RUO) in Japan

0.1 mL concentrate398M-14-RUO
0.5 mL concentrate398M-15-RUO
1 mL concentrate398M-16-RUO
1 mL predilute398M-17-RUO
7 mL predilute398M-18-RUO

 

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