Parvalbumin (2E11) Mouse Monoclonal Antibody

Parvalbumin
Parvalbumin antibody is expressed in tumor cells of chromophobe renal cell carcinoma in a cytoplasmic pattern.

Parvalbumin (2E11) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-10-13 10:19:35

Parvalbumin is a calcium-binding protein that regulates cytosolic calcium homeostasis.1-2 Tissue types that express this protein have been reported in the muscle, brain, neuroendocrine organs, and kidney.1-2 In normal kidney, parvalbumin has been shown to be limited to the distal tubular and collecting duct cells (the intercalated cells). 1-3 Parvalbumin is expressed in almost all primary, as well as metastatic, chromophobe renal cell carcinoma (RCC) and oncocytoma, but is rarely expressed  in other types of RCCs, such as clear cell RCC and papillary RCC.1-4 This limited expression has been considered in keeping with the putative histogenesis of chromophobe RCC and oncocytoma from the distal portion of the nephron and may facilitate in their differential diagnoses.1-4 

  1. Adley BP, et al. Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. Anal. Quant. Cytol. Histol. 2006; 28:228-36.
  2. Young AN, et al. Beta defensin-1, parvalbumin, and vimentin: a panel of diagnostic immunohistochemical markers for renal tumors derived from gene expression profiling studies using cDNA microarrays. Am J Surg Pathol. 2003; 27:199-205.
  3. Martignoni G, et al. Parvalbumin is constantly expressed in chromophobe renal carcinoma. Mod Pathol. 2001; 1:760-7.
  4. Teresa P, et al. Malignant effusion of chromophobe renal-cell carcinoma: cytological and immunohistochemical findings. Diagn Cytopathol 2012; 40:56-61.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: chromophobe renal cell carcinoma
  • Dilution Range: 1:10-1:50*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate396M-14
0.5 mL concentrate396M-15
1 mL concentrate396M-16
1 mL predilute396M-17
7 mL predilute396M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate396M-14
0.5 mL concentrate396M-15
1 mL concentrate396M-16
1 mL predilute396M-17
7 mL predilute396M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate396M-14
0.5 mL concentrate396M-15
1 mL concentrate396M-16
1 mL predilute396M-17
7 mL predilute396M-18

For research use only (RUO) in Japan

0.1 mL concentrate396M-14-RUO
0.5 mL concentrate396M-15-RUO
1 mL concentrate396M-16-RUO
1 mL predilute396M-17-RUO
7 mL predilute396M-18-RUO

 

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