Glutamine Synthetase (GS-6) Mouse Monoclonal Antibody

Glutamine Synthetase
Anti-glutamine synthetase strongly stains hepatocellular carcinoma cells in a cytoplasmic pattern.

Glutamine Synthetase (GS-6) Mouse Monoclonal Antibody

Specialties: Gastrointestinal (GI) Pathology

Updated: 2017-05-24 08:46:09

Glutamine synthetase (GS) catalyzes the synthesis of glutamine from glutamate and ammonia in the mammalian liver. In normal liver, GS expression is seen in centrilobular (zone 3) hepatocytes, but not in mid-zone (zone 2) or periportal (zone 3) hepatocytes. Glutamine, the end product of GS activity, is the major energy source of tumor cells. Based on findings from experimental hepatocarcinogenesis, GS-positive tumor cells are believed to be derived from GS-positive hepatocytes. Thus, anti-GS has been suggested as a marker for hepatocellular carcinoma (HCC).1-2

  1. Di Tommaso L, et al. Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology. 2007; 45:725-34.
  2. Nakamoto Y. Promising new strategies for hepatocellular carcinoma. Hepatol Res. 2016; 47:251-65.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: hepatocellular carcinoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate389M-14
0.5 mL concentrate389M-15
1 mL concentrate389M-16
1 mL predilute389M-17
7 mL predilute389M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate389M-14
0.5 mL concentrate389M-15
1 mL concentrate389M-16
1 mL predilute389M-17
7 mL predilute389M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate389M-14
0.5 mL concentrate389M-15
1 mL concentrate389M-16
1 mL predilute389M-17
7 mL predilute389M-18

For research use only (RUO) in Japan

0.1 mL concentrate389M-14-RUO
0.5 mL concentrate389M-15-RUO
1 mL concentrate389M-16-RUO
1 mL predilute389M-17-RUO
7 mL predilute389M-18-RUO

 

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