Napsin A (MRQ-60) Mouse Monoclonal Antibody

Napsin A
Lung adenocarcinoma tumor cells are stained by anti-napsin A.

Napsin A (MRQ-60) Mouse Monoclonal Antibody

Specialties: Cytopathology Pulmonary Pathology

Updated: 2017-05-24 08:46:09

Napsin is a pepsin-like aspartic proteinase in the A1 clan of the AA clade of proteinases.1-3 There are two closely related napsins, napsin A (NAPSA) and napsin B (NAPSB).1-3 Napsin A is involved in processing propeptide pulmonary surfactant protein B (proSP-B) in the lung.4 In normal tissue, Napsin A is expressed in type II pneumocytes of the lung and proximal tubules of the kidney.1-3 Napsin A is a useful marker for lung adenocarcinoma.1-3, 5-8

  1. Jagirdar J. Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung. Arch Pathol Lab Med. 2008; 132:384-96.
  2. Bishop JA, et al. Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma. Hum Pathol. 2010; 41:20-5.
  3. Rawlings ND and Salvesen GS. Handbook of Proteolytic Enzymes Volume 1. 3rd Edition. Academic Press. 2013; p.69-71.
  4. Brasch F, et al. Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. J Biol Chem. 2003; 278: 49006-14.
  5. Dejmek A, et al. Napsin A (TA02) is a useful alternative to thyroid transcription factor-1 (TTF-1) for the identification of pulmonary adenocarcinoma cells in pleural effusions. Diagn Cytopathol. 2007; 35:493-7.
  6. Inamura K, et al. Pulmonary adenocarcinomas with enteric differentiation: histologic and immunohistochemical characteristics compared with metastatic colorectal cancers and usual pulmonary adenocarcinomas. Am J Surg Pathol. 2005; 29:660-5.
  7. Ye J, et al. Combination of Napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung. Appl Immunohistochem Mol Morphol. 2011; 19:313-17.
  8. Mukhopadhyay S, et al. Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6. Am J Surg Pathol. 2011; 35:15-25.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: lung adenocarcinoma, kidney, renal cell carcinoma
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute352M-90
0.1 mL concentrate352M-94
0.5 mL concentrate352M-95
1 mL concentrate352M-96
1 mL predilute352M-97
7 mL predilute352M-98

For in vitro diagnostic (IVD) use in Canada

25 mL predilute352M-90
0.1 mL concentrate352M-94
0.5 mL concentrate352M-95
1 mL concentrate352M-96
1 mL predilute352M-97
7 mL predilute352M-98

For in vitro diagnostic (IVD) use in Europe

25 mL predilute352M-90
0.1 mL concentrate352M-94
0.5 mL concentrate352M-95
1 mL concentrate352M-96
1 mL predilute352M-97
7 mL predilute352M-98

For research use only (RUO) in Japan

25 mL predilute352M-90-RUO
0.1 mL concentrate352M-94-RUO
0.5 mL concentrate352M-95-RUO
1 mL concentrate352M-96-RUO
1 mL predilute352M-97-RUO
7 mL predilute352M-98-RUO

 

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