Lung adenocarcinoma tumor cells are stained by anti-napsin A.
Napsin A (MRQ-60) Mouse Monoclonal Antibody
Specialties: Cytopathology Pulmonary Pathology
Updated: 2022-07-05 13:37:48
Napsin is a pepsin-like aspartic proteinase in the A1 clan of the AA clade of proteinases.1-3 Napsin A is involved in processing propeptide pulmonary surfactant protein B (proSP-B) in the lung.4 In normal, benign tissue, Napsin A is expressed in type II pneumocytes of the lung and proximal tubules of the kidney.1-3 Napsin A is a useful marker for lung adenocarcinoma.1-3, 5-8
- Jagirdar, Jaishree. "Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung." Archives of pathology & laboratory medicine vol. 132,3 (2008): 384-96.
- Bishop, Justin A et al. "Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma." Human pathology vol. 41,1 (2010): 20-5.
- Rawlings ND and Salvesen GS. Handbook of Proteolytic Enzymes Volume 1. 3rd Edition. Academic Press. 2013; p.69-71.
- Brasch, Frank et al. "Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung." The Journal of biological chemistry vol. 278,49 (2003): 49006-14.
- Dejmek, Annika et al. "Napsin A (TA02) is a useful alternative to thyroid transcription factor-1 (TTF-1) for the identification of pulmonary adenocarcinoma cells in pleural effusions." Diagnostic cytopathology vol. 35,8 (2007): 493-7.
- Inamura, Kentaro et al. "Pulmonary adenocarcinomas with enteric differentiation: histologic and immunohistochemical characteristics compared with metastatic colorectal cancers and usual pulmonary adenocarcinomas." The American journal of surgical pathology vol. 29,5 (2005): 660-5.
- Ye, Jiqing et al. "Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung." Applied immunohistochemistry & molecular morphology : AIMM vol. 19,4 (2011): 313-7.
- Mukhopadhyay, Sanjay, and Anna-Luise A Katzenstein. "Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6." The American journal of surgical pathology vol. 35,1 (2011): 15-25.
Specifications
- Reactivity: paraffin
- Control: Lung Adenocarcinoma (Cytoplasmic); Kidney (Cytoplasmic); Renal Cell Carcinoma (Cytoplasmic)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 4.0 (CMC35229040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 352M-90 |
| 0.1 mL concentrate | 352M-94 |
| 0.5 mL concentrate | 352M-95 |
| 1.0 mL concentrate | 352M-96 |
| 1.0 mL predilute ready-to-use | 352M-97 |
| 7.0 mL predilute ready-to-use | 352M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 352M-90 |
| 0.1 mL concentrate | 352M-94 |
| 0.5 mL concentrate | 352M-95 |
| 1.0 mL concentrate | 352M-96 |
| 1.0 mL predilute ready-to-use | 352M-97 |
| 7.0 mL predilute ready-to-use | 352M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 352M-90 |
| 0.1 mL concentrate | 352M-94 |
| 0.5 mL concentrate | 352M-95 |
| 1.0 mL concentrate | 352M-96 |
| 1.0 mL predilute ready-to-use | 352M-97 |
| 7.0 mL predilute ready-to-use | 352M-98 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 352M-90-RUO |
| 0.1 mL concentrate (RUO) | 352M-94-RUO |
| 0.5 mL concentrate (RUO) | 352M-95-RUO |
| 1.0 mL concentrate (RUO) | 352M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 352M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 352M-98-RUO |
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