CD33 (PWS44) Mouse Monoclonal Antibody
Specialties: Hematopathology
CD33, also known as gp67 or SIGLEC-3, is a 67 kDa glycosylated transmembrane protein that is a member of the sialic acid-binding immunoglobulin-like lectin (siglec) family.1-3 Although the precise physiological function of CD33 is unknown, it may mediate cell to cell adhesion and modulate inflammatory and immune response.1-3 In normal tissue, anti-CD33 labels myeloid cells (especially myeloid precursors), liver Kupffer cells, lung alveolar macrophages, and placental syncytiotrophoblasts.2,3 In neoplastic tissue, anti-CD33 is useful for the identification of acute myeloid leukemia.2,3
- Freeman SD, et al. Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. Blood. 1995; 85:2005-12.
- Hoyer JD, et al. CD33 detection by immunohistochemistry in paraffin-embedded tissues: a new antibody shows excellent specificity and sensitivity for cells of myelomonocytic lineage. Am J Clin Pathol. 2008; 129:316-23.
- Laszlo GS, et al. Expression and functional characterization of CD33 transcript variants in human acute myeloid leukemia. Oncotarget. 2016; 7:43281-94.
Specifications
- Reactivity: paraffin
- Visualization: membranous
- Control: acute myeloid leukemia with monocytic differentiation or with minimal differentiation, placenta syncytiotrophoblasts
- Dilution Range: 1:20-1:80*
Package Inserts
IFU
- IVD Rev. 2.0 (CMC13321020)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 133M-14 |
| 0.5 mL concentrate | 133M-15 |
| 1 mL concentrate | 133M-16 |
| 1 mL predilute | 133M-17 |
| 7 mL predilute | 133M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 133M-14 |
| 0.5 mL concentrate | 133M-15 |
| 1 mL concentrate | 133M-16 |
| 1 mL predilute | 133M-17 |
| 7 mL predilute | 133M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 133M-14 |
| 0.5 mL concentrate | 133M-15 |
| 1 mL concentrate | 133M-16 |
| 1 mL predilute | 133M-17 |
| 7 mL predilute | 133M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 133M-14-RUO |
| 0.5 mL concentrate | 133M-15-RUO |
| 1 mL concentrate | 133M-16-RUO |
| 1 mL predilute | 133M-17-RUO |
| 7 mL predilute | 133M-18-RUO |
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