MSH6 (SP93) Rabbit Monoclonal Antibody

MSH6
Colon adenoma is highlighted by rabbit monoclonal MSH6 antibody in a nuclear pattern.

MSH6 (SP93) Rabbit Monoclonal Antibody

Specialties: Gastrointestinal (GI) Pathology

Updated: 2018-01-11 12:17:34

MSH6 is a mismatch repair protein which is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been suggested that the deficiencies in DNA mismatch repair protein(s) can be seen in some malignancies such as hereditary nonpolyposis colorectal cancer (HNPCC) and endometrial cancer. Anti-MSH6 may be useful in the identification of the MSH6 protein in a variety of normal and neoplastic tissues and the identification of loss of MSH6 in tumors with MSI genotype.1-6 Anti-MSH6 is best utilized in an IHC panel that includes anti-MLH1, anti-MSH2, and anti-PMS2.

  1. Lagerstedt Robinson K, et al. Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics. J Natl Cancer Inst. 2007; 99: 291-9. 
  2. Niessen RC, et al. Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis colorectal cancer. Gut. 2006; 55:1781-8. 
  3. Hansen TP, et al. Optimization of antibodies for detection of the mismatch repair proteins MLH1, MSH2, MSH6, and PMS2 using a biotin-free visualization system. Appl Immunohistochem Mol Morphol. 2006; 14:115-21. 
  4. Lawes DA, et al. The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers. Br J Cancer. 2005; 93:472-7. 
  5. Stormorken AT, et al. Immunohistochemistry identifies carriers of mismatch repair gene defects causing hereditary nonpolyposis colorectal cancer. J Clin Oncol. 2005; 23:4705-12. 
  6. Rigau V, et al. Microsatellite instability in colorectal carcinoma. The comparison of immunohistochemistry and molecular biology suggests a role for hMSH6 [correction of hMLH6] immunostaining. Arch Pathol Lab Med. 2003; 127:694-700. 

Specifications


  • Reactivity: paraffin
  • Control: Colorectal carcinoma (Nuclear)
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate287R-24
0.5 mL concentrate287R-25
1.0 mL concentrate287R-26
1.0 mL predilute ready-to-use287R-27
7.0 mL predilute ready-to-use287R-28

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate287R-24
0.5 mL concentrate287R-25
1.0 mL concentrate287R-26
1.0 mL predilute ready-to-use287R-27
7.0 mL predilute ready-to-use287R-28

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate287R-24
0.5 mL concentrate287R-25
1.0 mL concentrate287R-26
1.0 mL predilute ready-to-use287R-27
7.0 mL predilute ready-to-use287R-28

For research use only (RUO) in Japan

0.1 mL concentrate (RUO)287R-24-RUO
0.5 mL concentrate (RUO)287R-25-RUO
1.0 mL concentrate (RUO)287R-26-RUO
1.0 mL predilute ready-to-use (RUO)287R-27-RUO
7.0 mL predilute ready-to-use (RUO)287R-28-RUO

 

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