CD71 (MRQ-48) Mouse Monoclonal Antibody

CD71
Bone marrow erythroid precursors demonstrate a strong membranous/cytoplasmic expression of CD71 protein.

CD71 (MRQ-48) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

CD71, also known as transferrin receptor, is a membrane glycoprotein that mediates the uptake of iron from transferrin for hemoglobin synthesis in erythroid cells.1 Early erythroid precursors and erythroblasts contain the highest mass of transferrin receptors, and expression is lost as these cells cease hemoglobin synthesis and mature into erythrocytes.1 Therefore, anti-CD71 is a useful marker for highlighting erythroid precursors in bone marrow specimens.2

Increased CD71 expression is also associated with active cell growth including neoplastic tumor growth and may be seen in various carcinomas such as thyroid carcinomas, lung carcinomas, breast carcinomas, hepatocellular carcinomas and colorectal carcinomas.3

  1. Ponka P, et al. The transferrin receptor: role in health and disease. Int J Biochem Cell Biol. 1999; 31:1111-37.
  2. Marsee DK, et al. CD71 (transferrin receptor): an effective marker for erythroid precursors in bone marrow biopsy specimens. Am J Clin Pathology. 2010; 13:429-35.
  3. Chan KT, et al. Overexpression of transferrin receptor CD71 and its tumorigenic properties in esophageal squamous cell carcinoma. Oncol Rep. 2014; 31:1296-304.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: bone marrow
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate171M-94
0.5 mL concentrate171M-95
1 mL concentrate171M-96
1 mL predilute171M-97
7 mL predilute171M-98

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate171M-94
0.5 mL concentrate171M-95
1 mL concentrate171M-96
1 mL predilute171M-97
7 mL predilute171M-98

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate171M-94
0.5 mL concentrate171M-95
1 mL concentrate171M-96
1 mL predilute171M-97
7 mL predilute171M-98

For research use only (RUO) in Japan

0.1 mL concentrate171M-94-RUO
0.5 mL concentrate171M-95-RUO
1 mL concentrate171M-96-RUO
1 mL predilute171M-97-RUO
7 mL predilute171M-98-RUO

 

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