Cell Marque Portfolio

CD71 (MRQ-48)

Mouse Monoclonal


The transferrin receptor (CD71) is most highly expressed on placental syncytiotrophoblasts, myocytes, basal keratinocytes, hepatocytes, endocrine pancreas, spermatocytes, and erythroid precursors1. The level of transferrin receptor expression is highest in early erythroid precursors through the intermediate normoblast phase, after which expression decreases through the reticulocyte phase.2,3,4 The maturation of erythrocytes results in loss of transferrin receptor expression, in concert with down-regulation of the machinery for hemoglobin synthesis. The high level of transferrin receptor within erythroid precursors makes it an excellent marker for evaluation of erythroid components within bone marrow. Anti-CD71 is a highly effective marker for highlighting erythroid precursors in bone marrow biopsy specimens and shows the following features: 1) distinct membranous and cytoplasmic staining pattern, which is easily recognized in bone marrow biopsy; 2) restriction to erythroid lineage within bone marrow biopsy specimens; 3) CD71 expression decreases with the maturation of erythrocytes, with the highest level seen in early forms and the lowest level in late normoblast stage, and most importantly; 4) mature erythrocytes do not express CD71, which facilitates bone marrow analyses.5 Anti-CD71 is useful in identifying erythroid precursors with very little interference from mature erythrocytes and also in the determination of erythroid leukemia, benign erythroid proliferative disorders, and myelodysplastic syndrome, although further studies are needed for making a definitive diagnosis of MDS.5

Specialties: Hematopathology

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: bone marrow
  • Isotype: IgG1
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

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Last updated: 2016-01-07 14:13:45

CD71
Bone marrow erythroid precursors demonstrate a strong membranous/cytoplasmic expression of CD71 protein.

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Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: bone marrow
  • Isotype: IgG1
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

Download an IFU

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 171M-94
0.5 ml, concentrate 171M-95
1 ml, concentrate 171M-96
1 ml, predilute 171M-97
7 ml, predilute 171M-98

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 171M-94
0.5 ml, concentrate 171M-95
1 ml, concentrate 171M-96
1 ml, predilute 171M-97
7 ml, predilute 171M-98

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 171M-94
0.5 ml, concentrate 171M-95
1 ml, concentrate 171M-96
1 ml, predilute 171M-97
7 ml, predilute 171M-98

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 171M-94 (RUO)
0.5 ml, concentrate 171M-95 (RUO)
1 ml, concentrate 171M-96 (RUO)
1 ml, predilute 171M-97 (RUO)
7 ml, predilute 171M-98 (RUO)

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: bone marrow
  • Isotype: IgG1
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

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