PAX-8 Rabbit Polyclonal Antibody

PAX-8
Nuclear staining by PAX-8 antibody on ovarian serous carcinoma.

PAX-8 Rabbit Polyclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

PAX-8 is a transcription factor expressed during embryonic development of Müllerian organs, kidney, and thyroid, with continued expression in some epithelial cell types of these mature tissues.1  It can be useful for marking several types of carcinoma including ovarian serous carcinoma, clear cell renal cell carcinoma, and papillary thyroid carcinoma.1-5  Additionally, PAX-8 is not found in the epithelial cells of the breast, lung, mesothelium, stomach, colon, pancreas and other sites.1-4

  1. Ozcan A, et al. PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study. Mod Pathol. 2011; 24:751-64.
  2. Laury AR, et al. A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol. 2011; 35:816-26.
  3. Nonaka, D et al. Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. Am J Surg Pathol. 2008; 32:1566-71.
  4. Nonaka, D et al. Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (Fox E1) in thyroid epithelial neoplasms. Mod Pathol. 2008; 21:192-200.
  5. Tong, GX et al. Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study. Mod Pathol. 2009; 22:1218-27.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: non-mucinous ovarian carcinoma, thyroid carcinoma, renal cell carcinoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate363A-14
0.5 mL concentrate363A-15
1 mL predilute363A-17
7 mL predilute363A-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate363A-14
0.5 mL concentrate363A-15
1 mL predilute363A-17
7 mL predilute363A-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate363A-14
0.5 mL concentrate363A-15
1 mL predilute363A-17
7 mL predilute363A-18

For research use only (RUO) in Japan

0.1 mL concentrate363A-14-RUO
0.5 mL concentrate363A-15-RUO
1 mL predilute363A-17-RUO
7 mL predilute363A-18-RUO

 

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