p21WAF1 (DCS-60.2) Mouse Monoclonal Antibody

p21<sup>WAF1</sup>
Anti-p21 labels nuclei of many epithelial cells and lymphocytes in colon mucosa.

p21WAF1 (DCS-60.2) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

p21WAF1/CIP1 is a cyclin-dependent kinase (CDK) inhibitor that plays a role in cell cycle control. In humans, p21 is a 21kD protein of the cyclin dependent kinase inhibitor 1A (CDKN1A) gene.  p21 acts as an inhibitor of cell cycle progression at the G1 phase and is tightly controlled by p53. It is expressed in normal human tissue and a wide array of tumors.1-3

  1. DiGiuseppe JA, et al. p53-independent expression of cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma. Am J Pathol. 1995; 147:884-8.
  2. Xie HL, et al. Expression of p21(WAF1) and p53 and polymorphism of p21(WAF1) gene in gastric carcinoma. World J Gastroenterol. 2004; 10(8):1125-31.
  3. Stein JP, et al. Effect of p21WAF1/CIP1 expression on tumor progression in bladder cancer. J of Natl Cancer Inst. 1998; 90:1072-8.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate421M-14
0.5 mL concentrate421M-15
1 mL concentrate421M-16
1 mL predilute421M-17
7 mL predilute421M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate421M-14
0.5 mL concentrate421M-15
1 mL concentrate421M-16
1 mL predilute421M-17
7 mL predilute421M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate421M-14
0.5 mL concentrate421M-15
1 mL concentrate421M-16
1 mL predilute421M-17
7 mL predilute421M-18

For research use only (RUO) in Japan

0.1 mL concentrate421M-14-RUO
0.5 mL concentrate421M-15-RUO
1 mL concentrate421M-16-RUO
1 mL predilute421M-17-RUO
7 mL predilute421M-18-RUO

 

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