C4d Rabbit Polyclonal Antibody

C4d
C4d (polyclonal) on kidney.

C4d Rabbit Polyclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Acute humoral rejection is mediated by antibodies to the donor endothelium that activate the classical complement pathway.1-3 This leads to a number of split products of complement proteins. C4d is a fragment of C 4 complement released during activation of the classic complement pathway by the antigen antibody complex.3 C4d deposits in peritubular capillaries and is regarded as an indirect sign of an antibody response.3,6 C4d can be a useful tool for indicating acute renal allograft rejection.1-6

  1. Jianghua C, et al. Clin Transplant. 2005; 19:785-91.
  2. Kayler LK, et al. Transplantation. 2008; 85:813-20.
  3. Ranjan P, et al. Nephrol Dial Transplant .2008; 23:1735-41.
  4. Nadasdy GM, et al. Hum Pathol. 2005; 36:1178-85.
  5. Seemayer CA, et al. Nephrol Dial Transplant. 2007; 22:568-76.
  6. Bouron-Dal Soglio D, et al. Hum Pathol. 2008; 39:1103-10.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lymph node, tonsil, acute rejected kidney transplant
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate404A-14
0.5 mL concentrate404A-15
1 mL concentrate404A-16
1 mL predilute404A-17
7 mL predilute404A-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate404A-14
0.5 mL concentrate404A-15
1 mL concentrate404A-16
1 mL predilute404A-17
7 mL predilute404A-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate404A-14
0.5 mL concentrate404A-15
1 mL concentrate404A-16
1 mL predilute404A-17
7 mL predilute404A-18

For research use only (RUO) in Japan

0.1 mL concentrate404A-14-RUO
0.5 mL concentrate404A-15-RUO
1 mL concentrate404A-16-RUO
1 mL predilute404A-17-RUO
7 mL predilute404A-18-RUO

 

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