TCL1 (MRQ-7) Mouse Monoclonal Antibody

TCL1
Nuclear labelling of Burkitt lymphoma by TCL1 antibody.

TCL1 (MRQ-7) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

T-cell leukemia/lymphoma protein 1 (TCL1, TCL1A, p14TCL1) is a 14 kDa product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (T-PLL). TCL1 protein is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. TCL1 is expressed in differentiated B-cells under both reactive and neoplastic conditions, antigen committed B-cells, and in germinal center B-cells. The Anti-TCL1 immunohistochemical reactivity is reportedly useful identifying B-cell lymphomas including follicular lymphoma and Burkitt lymphoma.1-10

  1. Narducci MG, et al. Regulation of TCL1 expression in B- and T-cell lymphomas and reactive lymphoid tissues. Cancer Res. 2000; 60:2095-100.
  2. Roos J, et al. Expression of TCL1 in hematologic disorders. Pathobiology. 2001; 69:59-66.
  3. Pescarmona E, et al. Expression of TCL1 and CD27 in primary cutaneous B-cell lymphomas. Histopathology. 2006; 49:343-8.
  4. Rodig SJ, et al. Characteristic expression patterns of TCL1, CD 38, and CD44 identify aggressive lymphomas harboring MYC translocation. Am J Surg Pathol. 2008; 32:113-22.
  5. Nakayama I, et al. Activation of the TCL1 protein in B cell lymphomas. Pathol Int. 2000; 50:191-9.
  6. Pekarsky Y, et al. The role of TCL1 in human leukemia. Oncogene. 2001; 20:5638-43.
  7. Pekarsky Y, et al. TCL1 as a model for lymphomagenesis. Hematol Oncol Clin North Am. 2004; 18:863-79.
  8. Takizawa J, et al. Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia. Jpn J Cancer Res. 1998; 89:712-8.
  9. Bichi R, et al. Huamn chronic lymphocytic leukemia modeled in mouse targeted TCL1 expression. Proc Natl Acad Sci USA. 2002; 99:6955-60.
  10. Herling M, et al. TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state. Leukemia. 2006; 20:280-5.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, nuclear
  • Control: tonsil, B-cell lymphoma
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate357M-14
0.5 mL concentrate357M-15
1 mL concentrate357M-16
1 mL predilute357M-17
7 mL predilute357M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate357M-14
0.5 mL concentrate357M-15
1 mL concentrate357M-16
1 mL predilute357M-17
7 mL predilute357M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate357M-14
0.5 mL concentrate357M-15
1 mL concentrate357M-16
1 mL predilute357M-17
7 mL predilute357M-18

For research use only (RUO) in Japan

0.1 mL concentrate357M-14-RUO
0.5 mL concentrate357M-15-RUO
1 mL concentrate357M-16-RUO
1 mL predilute357M-17-RUO
7 mL predilute357M-18-RUO

 

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