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p120 Catenin (MRQ-5)

Mouse Monoclonal


p120 catenin is encoded on chromosome 11q11. Alpha-catenin and beta-catenin bind to the intracellular domain of E-cadherin while p120 catenin binds E-cadherin at a juxta-membrane site.1 The complex stabilizes tight junctions. In the cell, p120 catenin localized to the E-cadherin/catenins cell adhesion complex, directly associates with cytoplasmic C-terminus of E-cadherin and may similarly interact with other cadherins.2 A deficiency of E-cadherin results in the intracytoplasmic accumulation of p120 catenin. Lobular carcinoma of the breast shows intracytoplasmic accumulation of p120 catenin while ductal carcinoma shows reduced membrane p120 catenin without cytoplasmic accumulation.3,4 In gastric and colonic carcinoma, strong cytoplasmic p120 catenin is associated with discohesive infiltrative morphology.5,6

Specialties: Breast/Gynecological Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lobular breast carcinoma
  • Isotype: IgG1
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C
  • Leica Bond
    Protocol F: ER2/20

Package Inserts


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SDS

References


  1. Reynolds AB, et al. Oncogene. 1992; 7:2439-2445.
  2. Thoreson MA, et al. Mol Cell Biol. 1994; 14:8333-8342.
  3. Sarrio D, et al. Oncogene. 2004; 23:3272-83.
  4. Dabbs DJ, et al. Am J Surg Pathol. 2007; 31:427-437.
  5. Jawhari AW, et al. J Pathol. 1999; 189:180-5.
  6. Bellovon DI, et al. Cancer Res. 2005; 65;10938-45.

Last updated: 2017-05-24 08:46:09

p120 Catenin
p120 Catenin antibody is strongly positive for invasive lobular carcinoma. On the left, p120 stains membranous for normal ducts. While on the right, it labels invasive lobular carcinoma in a cytoplasmic pattern.

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Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lobular breast carcinoma
  • Isotype: IgG1
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C
  • Leica Bond
    Protocol F: ER2/20

References


  1. Reynolds AB, et al. Oncogene. 1992; 7:2439-2445.
  2. Thoreson MA, et al. Mol Cell Biol. 1994; 14:8333-8342.
  3. Sarrio D, et al. Oncogene. 2004; 23:3272-83.
  4. Dabbs DJ, et al. Am J Surg Pathol. 2007; 31:427-437.
  5. Jawhari AW, et al. J Pathol. 1999; 189:180-5.
  6. Bellovon DI, et al. Cancer Res. 2005; 65;10938-45.

Package Inserts

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Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate 420M-14
0.5 mL concentrate 420M-15
1 mL concentrate 420M-16
1 mL predilute 420M-17
7 mL predilute 420M-18
25 mL predilute 420M-10

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate 420M-14
0.5 mL concentrate 420M-15
1 mL concentrate 420M-16
1 mL predilute 420M-17
7 mL predilute 420M-18
25 mL predilute 420M-10

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate 420M-14
0.5 mL concentrate 420M-15
1 mL concentrate 420M-16
1 mL predilute 420M-17
7 mL predilute 420M-18
25 mL predilute 420M-10

For research use only (RUO) in Japan

0.1 mL concentrate 420M-14-RUO
0.5 mL concentrate 420M-15-RUO
1 mL concentrate 420M-16-RUO
1 mL predilute 420M-17-RUO
7 mL predilute 420M-18-RUO
25 mL predilute 420M-10-RUO

 

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Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lobular breast carcinoma
  • Isotype: IgG1
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C
  • Leica Bond
    Protocol F: ER2/20

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References


  1. Reynolds AB, et al. Oncogene. 1992; 7:2439-2445.
  2. Thoreson MA, et al. Mol Cell Biol. 1994; 14:8333-8342.
  3. Sarrio D, et al. Oncogene. 2004; 23:3272-83.
  4. Dabbs DJ, et al. Am J Surg Pathol. 2007; 31:427-437.
  5. Jawhari AW, et al. J Pathol. 1999; 189:180-5.
  6. Bellovon DI, et al. Cancer Res. 2005; 65;10938-45.
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