Granzyme B Rabbit Polyclonal Antibody

Granzyme B
Granzyme B antibody labels in a granular/cytoplasmic pattern for NK/T-cell lymphoma.

Granzyme B Rabbit Polyclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

Granzyme B is a serine protease expressed by cytotoxic T lymphocytes and natural killer (NK) cells and initiates apoptosis through multiple direct and indirect pathways.1 Both neoplasm of lymphoid and non-lymphoid origin exhibit positivity for anti-Granzyme B.1 Anti-Granzyme B has also been found to be useful in identifying natural killer/T-cell lymphoma, as well as anaplastic large cell lymphoma.1-5

  1. Kummer JA, et al. Localization and identification of granzymes A and B-expressing cells in normal human lymphoid tissue and peripheral blood. Clin Exp Immunol. 1995; 100:164-72.
  2. Oudejans JJ, et al. Granzyme B expression in Reed-Sternberg cells of Hodgkin's disease. Am J Pathol. 1996; 148:233-40.
  3. Oudejans JJ, et al. Activated cytotoxic T cells as prognostic marker in Hodgkin's disease. Blood. 1997; 89:1376-82.
  4. Kato N, et al. Neutrophil-rich anaplastic large cell lymphoma presenting in the skin. Am J Dermatopathol. 2003; 25:142-7.
  5. Liu J, et al. Nasal natural killer/T cell lymphoma with cutaneous involvement: case report and Chinese literature review reported in China mainland. J Dermatol. 2003; 30:735-41.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: spleen, anaplastic large cell lymphoma
  • Dilution Range: 1:10-1:50*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate262A-14
0.5 mL concentrate262A-15
1 mL concentrate262A-16
1 mL predilute262A-17
7 mL predilute262A-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate262A-14
0.5 mL concentrate262A-15
1 mL concentrate262A-16
1 mL predilute262A-17
7 mL predilute262A-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate262A-14
0.5 mL concentrate262A-15
1 mL concentrate262A-16
1 mL predilute262A-17
7 mL predilute262A-18

For research use only (RUO) in Japan

0.1 mL concentrate262A-14-RUO
0.5 mL concentrate262A-15-RUO
1 mL concentrate262A-16-RUO
1 mL predilute262A-17-RUO
7 mL predilute262A-18-RUO

 

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