BG8, Lewisy (F3) Mouse Monoclonal Antibody

BG8, Lewis<sup>y</sup>
BG8, LewisY (F3) on lung.

BG8, Lewisy (F3) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Blood group Lewis carbohydrate determinants are oligosaccharides on glycolipids and glycoproteins. In healthy individuals the LewisY antigen is a type 2 antigen usually only expressed in low levels of a few cell types such as some epithelial cells. Reportedly these antigens are aberrantly expressed in high levels in many carcinomas. Anti-BG8, LewisY reactivity in immunohistochemistry is seen in carcinomas of the breast, lung, and colon.1-5

  1. Davidson B, et al. Detection of cancer cells in effusions from patients diagnosed with gynaecological malignancies. Evaluation of five epithelial markers. Virchows Arch. 1999; 435:43-9.
  2. King JE, et al. Sensitivity and specificity of immunohistochemical markers used in the diagnosis of epithelioid mesothelioma: a detailed systematic analysis using published data.Histopathology. 2006; 48:223-32.
  3. Marchevsky AM et al. Evidence-based guidelines for the utilization of immunostains in diagnostic pathology: pulmonary adenocarcinoma versus mesothelioma. Appl Immunohistochem Mol Morphol. 2007; 15:140-4.
  4. Ordonez NG. The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma. Am J Surg Pathol. 2003; 27:1031-51.
  5. Ordóñez NG. Value of thyroid transcription factor-1, E-cadherin, BG8, WT1, and CD44S immunostaining in distinguishing epithelial pleural mesothelioma from pulmonary and non-pulmonary adenocarcinoma. Am J Surg Pathol. 2000; 24:598-606.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: lung adenocarcinoma
  • Dilution Range: 1:10-1:50*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate228M-14
0.5 mL concentrate228M-15
1 mL concentrate228M-16
1 mL predilute228M-17
7 mL predilute228M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate228M-14
0.5 mL concentrate228M-15
1 mL concentrate228M-16
1 mL predilute228M-17
7 mL predilute228M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate228M-14
0.5 mL concentrate228M-15
1 mL concentrate228M-16
1 mL predilute228M-17
7 mL predilute228M-18

For research use only (RUO) in Japan

0.1 mL concentrate228M-14-RUO
0.5 mL concentrate228M-15-RUO
1 mL concentrate228M-16-RUO
1 mL predilute228M-17-RUO
7 mL predilute228M-18-RUO

 

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