BG8, LewisY (F3) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Blood group Lewis carbohydrate determinants are oligosaccharides on glycolipids and glycoproteins. In healthy individuals the LewisY antigen is a type 2 antigen usually only expressed in low levels of a few cell types such as some epithelial cells. Reportedly these antigens are aberrantly expressed in high levels in many carcinomas. Anti-BG8, LewisY reactivity in immunohistochemistry is seen in carcinomas of the breast, lung, and colon.1-5
- Davidson B, et al. Detection of cancer cells in effusions from patients diagnosed with gynaecological malignancies. Evaluation of five epithelial markers. Virchows Arch. 1999; 435:43-9.
- King JE, et al. Sensitivity and specificity of immunohistochemical markers used in the diagnosis of epithelioid mesothelioma: a detailed systematic analysis using published data.Histopathology. 2006; 48:223-32.
- Marchevsky AM et al. Evidence-based guidelines for the utilization of immunostains in diagnostic pathology: pulmonary adenocarcinoma versus mesothelioma. Appl Immunohistochem Mol Morphol. 2007; 15:140-4.
- Ordonez NG. The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma. Am J Surg Pathol. 2003; 27:1031-51.
- Ordóñez NG. Value of thyroid transcription factor-1, E-cadherin, BG8, WT1, and CD44S immunostaining in distinguishing epithelial pleural mesothelioma from pulmonary and non-pulmonary adenocarcinoma. Am J Surg Pathol. 2000; 24:598-606.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: lung adenocarcinoma
- Dilution Range: 1:10-1:50 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC22821050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 228M-14 |
| 0.5 mL concentrate | 228M-15 |
| 1 mL concentrate | 228M-16 |
| 1 mL predilute | 228M-17 |
| 7 mL predilute | 228M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 228M-14 |
| 0.5 mL concentrate | 228M-15 |
| 1 mL concentrate | 228M-16 |
| 1 mL predilute | 228M-17 |
| 7 mL predilute | 228M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 228M-14 |
| 0.5 mL concentrate | 228M-15 |
| 1 mL concentrate | 228M-16 |
| 1 mL predilute | 228M-17 |
| 7 mL predilute | 228M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 228M-14-RUO |
| 0.5 mL concentrate | 228M-15-RUO |
| 1 mL concentrate | 228M-16-RUO |
| 1 mL predilute | 228M-17-RUO |
| 7 mL predilute | 228M-18-RUO |
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