PD-1 (NAT105) Mouse Monoclonal Antibody

PD-1
Scattered germinal center cells labelled with PD-1 antibody.

PD-1 (NAT105) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

Programmed death-1 (PD-1), also known as CD279, is a type-I transmembrane protein expressed on T-cells, B-cells, and monocytes during activation.1-2 PD-1 and its ligands (PD-L1 and PD-L2) function as an immune checkpoint pathway by regulating T-cell activation and autoimmunity.2 PD-1 labels follicular helper T-cells and is therefore a useful marker for angioimmunoblastic T-cell lymphoma.3-4

  1. Thibult ML, et al. Int Immunol. 2013; 25:129-37.
  2. Francisco L, et al. Immunol. 2010; 236:219-42.
  3. Dorfman DM, et al. Am J Surg Pathol. 2006; 30:802-10.
  4. Cogbill CH, et al. Am J Clin Pathol. 2014; 142:88-98.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: lymph node, tonsil
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate315M-94
0.5 mL concentrate315M-95
1 mL concentrate315M-96
1 mL predilute315M-97
7 mL predilute315M-98

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate315M-94
0.5 mL concentrate315M-95
1 mL concentrate315M-96
1 mL predilute315M-97
7 mL predilute315M-98

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate315M-94
0.5 mL concentrate315M-95
1 mL concentrate315M-96
1 mL predilute315M-97
7 mL predilute315M-98

For research use only (RUO) in Japan

0.1 mL concentrate315M-94-RUO
0.5 mL concentrate315M-95-RUO
1 mL concentrate315M-96-RUO
1 mL predilute315M-97-RUO
7 mL predilute315M-98-RUO

 

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