Perforin (MRQ-23) Mouse Monoclonal Antibody

Perforin
Anti-perforin expresses punctate cytoplasmic staining in NK/regulatory T-cells of the spleen.

Perforin (MRQ-23) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-26 11:34:12

Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis, the cell death program. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.1-3

  1. Chu PG, et al. Practical applications of immunohistochemistry in hematolymphoid neoplasms. Ann Diagn Pathol. 1999; 3:104-33.
  2. Bittmann I, et al. Fas/FasL and perforin/granzyme pathway in acute rejection and diffuse alveolar damage after allogeneic lung transplantation- a human biopsy study. Virchows Arch. 2004; 445:375-81.
  3. d’Amore ES, et al. Anaplastic large cell lymphomas: a study of 75 pediatric patients. Pediatr Dev Pathol. 2007; 10:181-91.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: spleen
  • Dilution Range: 1:10-1:50*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate316M-14
0.5 mL concentrate316M-15
1 mL concentrate316M-16
1 mL predilute316M-17
7 mL predilute316M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate316M-14
0.5 mL concentrate316M-15
1 mL concentrate316M-16
1 mL predilute316M-17
7 mL predilute316M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate316M-14
0.5 mL concentrate316M-15
1 mL concentrate316M-16
1 mL predilute316M-17
7 mL predilute316M-18

For research use only (RUO) in Japan

0.1 mL concentrate316M-14-RUO
0.5 mL concentrate316M-15-RUO
1 mL concentrate316M-16-RUO
1 mL predilute316M-17-RUO
7 mL predilute316M-18-RUO

 

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