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BCL2 (124)

Mouse Monoclonal


Bcl-2 family is the best characterized protein family involved in regulation of apoptotic cell death, consisting of anti-apoptotic and pro-apoptotic members. Bcl-2 is a useful marker for identifying neoplastic cells in follicular lymphoma. Antibodies specific for the Bcl-2 protein can be used to distinguish between reactive and neoplastic follicular proliferation in lymph node biopsies.1-4

Specialties: Hematopathology

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: tonsil
  • Isotype: IgG1/k
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Package Inserts


IFU SDS

References


  1. Tsujimoto, Y. Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria? Genes Cells. 1998; 3:697-707.
  2. Gaulard P, et al. Expression of the bcl-2 gene product in follicular lymphoma. Am J Pathol. 1992; 140: 1089-95.
  3. Wang T, et al. Bcl-2 oncoprotein is widespread in lymphoid tissue and lymphomas but its differential expression in benign versus malignant follicles and monocytoid B-cell proliferations is of diagnostic value. APMIS. 1995; 103:655-62.
  4. West RB, et al. The usefulness of immunohistochemistry in the diagnosis of follicular lymphoma in bone marrow biopsy specimens. Am J Clin Pathol. 2002; 117:636-43.

Last updated: 2017-06-01 11:04:26

BCL2
BCL2 (124) on tonsil.

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Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: tonsil
  • Isotype: IgG1/k
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

References


  1. Tsujimoto, Y. Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria? Genes Cells. 1998; 3:697-707.
  2. Gaulard P, et al. Expression of the bcl-2 gene product in follicular lymphoma. Am J Pathol. 1992; 140: 1089-95.
  3. Wang T, et al. Bcl-2 oncoprotein is widespread in lymphoid tissue and lymphomas but its differential expression in benign versus malignant follicles and monocytoid B-cell proliferations is of diagnostic value. APMIS. 1995; 103:655-62.
  4. West RB, et al. The usefulness of immunohistochemistry in the diagnosis of follicular lymphoma in bone marrow biopsy specimens. Am J Clin Pathol. 2002; 117:636-43.

Package Inserts

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Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute 226M-90
0.1 mL concentrate 226M-94
0.5 mL concentrate 226M-95
1 mL concentrate 226M-96
1 mL predilute 226M-97
7 mL predilute 226M-98

For in vitro diagnostic (IVD) use in Canada

25 mL predilute 226M-90
0.1 mL concentrate 226M-94
0.5 mL concentrate 226M-95
1 mL concentrate 226M-96
1 mL predilute 226M-97
7 mL predilute 226M-98

For in vitro diagnostic (IVD) use in Europe

25 mL predilute 226M-90
0.1 mL concentrate 226M-94
0.5 mL concentrate 226M-95
1 mL concentrate 226M-96
1 mL predilute 226M-97
7 mL predilute 226M-98

For research use only (RUO) in Japan

25 mL predilute 226M-90-RUO
0.1 mL concentrate 226M-94-RUO
0.5 mL concentrate 226M-95-RUO
1 mL concentrate 226M-96-RUO
1 mL predilute 226M-97-RUO
7 mL predilute 226M-98-RUO

 

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Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: tonsil
  • Isotype: IgG1/k
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

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References


  1. Tsujimoto, Y. Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria? Genes Cells. 1998; 3:697-707.
  2. Gaulard P, et al. Expression of the bcl-2 gene product in follicular lymphoma. Am J Pathol. 1992; 140: 1089-95.
  3. Wang T, et al. Bcl-2 oncoprotein is widespread in lymphoid tissue and lymphomas but its differential expression in benign versus malignant follicles and monocytoid B-cell proliferations is of diagnostic value. APMIS. 1995; 103:655-62.
  4. West RB, et al. The usefulness of immunohistochemistry in the diagnosis of follicular lymphoma in bone marrow biopsy specimens. Am J Clin Pathol. 2002; 117:636-43.
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