Cytokeratin 5 (EP1601Y) Rabbit Monoclonal Antibody

Cytokeratin 5
Cytokeratin 5 antibody labels squamous elements in the basal epidermis and sebaceous glands.

Cytokeratin 5 (EP1601Y) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Cytokeratin 5 is an intermediate filament protein of 58 kD molecular weight within the cytokeratin family. It is a type II (basic) cytokeratin. Antibodies to this protein identify basal cells of squamous and glandular epithelia, myoepithelia, and mesothelium.1 Anti-cytokeratin 5 has been reported useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelioid mesothelioma.2 Epithelioid mesotheliomas are strongly positive in almost all cases, but a minority of pulmonary adenocarcinomas will show focal immunoreactivity.2 Almost all squamous cell carcinomas, half of transitional carcinomas, and many undifferentiated large cell carcinomas immunostain with anti-CK 5.3 Anti-CK 5, along with anti-p63, affords a high sensitivity and specificity for squamous differentiation. Myoepithelial cells of the breast,4,5 glandular epithelia, and basal cells of the prostate are labeled with anti-CK 5.6 This antibody, along with anti-CK 14, has found application in identifying basal-like breast carcinoma.5,7

  1. Dabbs DJ. Diagnostic Immunohistochemistry. 4th Edition. Elsevier Saunders, Philadelphia, PA. 2014 p. 212.
  2. Ordonez NG. Human Pathology. 2007; 38:1–16.
  3. Kargi A, et al. Appl Immunohistochem Mol Morphol. 2007; 15:415–420.
  4. Clarke CL, et al. J Pathol. 2004; 204:147-52.
  5. Dabbs DJ, et al. Mod Pathol. 2006; 19:1506-11.
  6. Dabbs DJ. Diagnostic Immunohistochemistry. 4th Edition. Elsevier Saunders, Philadelphia, PA. 2014 p. 212.
  7. Livasy CA, et al. Hum Pathol. 2007; 38:197-204.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: mesothelioma, prostate
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate305R-14
0.5 mL concentrate305R-15
1 mL concentrate305R-16
1 mL predilute305R-17
7 mL predilute305R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate305R-14
0.5 mL concentrate305R-15
1 mL concentrate305R-16
1 mL predilute305R-17
7 mL predilute305R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate305R-14
0.5 mL concentrate305R-15
1 mL concentrate305R-16
1 mL predilute305R-17
7 mL predilute305R-18

For research use only (RUO) in Japan

0.1 mL concentrate305R-14-RUO
0.5 mL concentrate305R-15-RUO
1 mL concentrate305R-16-RUO
1 mL predilute305R-17-RUO
7 mL predilute305R-18-RUO

 

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