MUC2 (MRQ-18) Mouse Monoclonal Antibody

MUC2
MUC2 antibody labels hyperplastic colon polyp.

MUC2 (MRQ-18) Mouse Monoclonal Antibody

Specialties: Gastrointestinal (GI) Pathology

Updated: 2017-05-24 08:46:09

Mucins are high molecular weight glycoproteins which constitute the major component of the mucus layer that protects the gastric epithelium from chemical and mechanical injury.1 In humans, at least 14 mucin genes have been identified that code for the mucin proteins. Reportedly, mucin expression is associated with tumor type of gastric carcinomas, with MUC2 being associated with mucinous carcinomas.2-4 Anti- MUC2 reactivity is seen in goblet cells of the small intestine and colon, and it is useful in immunohistochemistry for identifying colonic, gastric and esophageal carcinomas.5-7

  1. Chaves P, et al. Gastric and intestinal differentiation in Barrett’s metaplasia and associ­ated adenocarcinoma. Dis Esophagus. 2005; 18:383-7.
  2. Leteurtre E, et al. Relationships between mucinous gas­tric carcinoma, MUC2 expression and survival. World J Gastroenterol. 2006; 12:3324-31.
  3. Mino-Kenudson M, et al. Mucin expression in reactive gastropathy: an immunohistochemical analysis. Arch Pathol Lab Med. 2007; 131:86-90.
  4. Mizoshita T, et al. Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon. Histol Histopathol. 2007; 22:251-60.
  5. O’Connell FP, et al. Utility of immunohistochemistry in distinguishing primary adenocarcinomas from metastatic breast carcinomas in the gastrointestinal tract. Arch Pathol Lab Med. 2005; 129:338-47.
  6. Park SY, et al. Panels of immunohistochemical markers help determine primary sites of metastatic adenocarcinoma. Arch Pathol Lab Med. 2007; 131:1561-7.
  7. Rakha EA, et al. Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer. Mod Pathol. 2005; 18:1295-304.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: colon
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate291M-14
0.5 mL concentrate291M-15
1 mL concentrate291M-16
1 mL predilute291M-17
7 mL predilute291M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate291M-14
0.5 mL concentrate291M-15
1 mL concentrate291M-16
1 mL predilute291M-17
7 mL predilute291M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate291M-14
0.5 mL concentrate291M-15
1 mL concentrate291M-16
1 mL predilute291M-17
7 mL predilute291M-18

For research use only (RUO) in Japan

0.1 mL concentrate291M-14-RUO
0.5 mL concentrate291M-15-RUO
1 mL concentrate291M-16-RUO
1 mL predilute291M-17-RUO
7 mL predilute291M-18-RUO

 

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