Cytokeratin 17 (Ks 17.E3) Mouse Monoclonal Antibody

Cytokeratin 17
Benign cervical epithelium is stained by cytokeratin 17 antibody predominately at the basal layers. In the superficial levels, staining by the antibody diminishes until completely negative.

Cytokeratin 17 (Ks 17.E3) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Cytokeratin 17 is a 46-kD intermediate filament protein found in basal cells of complex epithelia, such as bronchial epithelial cells, nail beds, sebaceous glands, and is involved in the formation and maintenance of various skin appendages such as hair follicles. Anti-Cytokeratin 17 is a useful immunohistochemical reagent for identifying basal cell differentiation and squamous cell carcinomas.1-4

  1. Regauer S, et al. CK17 and p16 expression patterns distinguish (atypical) immature squamous metaplasia from high-grade cervical intraepithelial neoplasia (CIN III). Histopathology. 2007; 50:629-35.
  2. Chu PG, et al. Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Am J Surg Pathol. 2005; 29:359-67.
  3. Cohen-Kerem R, et al. Cytokeratin-17 as a potential marker for squamous cell carcinoma of the larynx. Ann Otol Rhinol Laryngol. 2004; 113:821-7.
  4. Martens JE, et al. Cytokeratin 17 and p63 are markers of the HPV target cell, the cervical stem cell. Anticancer Res. 2004; 24:771-5.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: cervix immature metaplasia, breast
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate317M-14
0.5 mL concentrate317M-15
1 mL concentrate317M-16
1 mL predilute317M-17
7 mL predilute317M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate317M-14
0.5 mL concentrate317M-15
1 mL concentrate317M-16
1 mL predilute317M-17
7 mL predilute317M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate317M-14
0.5 mL concentrate317M-15
1 mL concentrate317M-16
1 mL predilute317M-17
7 mL predilute317M-18

For research use only (RUO) in Japan

0.1 mL concentrate317M-14-RUO
0.5 mL concentrate317M-15-RUO
1 mL concentrate317M-16-RUO
1 mL predilute317M-17-RUO
7 mL predilute317M-18-RUO

 

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