Calponin-1 (EP798Y) Rabbit Monoclonal Primary Antibody
Specialties: Anatomic Pathology
Calponin is a 34-kD polypeptide that interacts with actin, tropomyosin, and calmodulin. It is involved in smooth muscle contraction mechanism and is restricted exclusively to smooth muscle tissue. Anti-calponin has been found to be useful in staining myoepithelium and thus has been used to confirm the presence of myoepithelial cells in benign breast proliferations and their absence in invasive breast carcinomas.1 Calponin positivity has also been noted in myoepithelial neoplasms2,4 and pleomorphic adenoma3 of salivary gland.
- Hill, Cheryl B, and I-Tien Yeh. "Myoepithelial cell staining patterns of papillary breast lesions: from intraductal papillomas to invasive papillary carcinomas." American journal of clinical pathology vol. 123,1 (2005): 36-44.
- Nagao, T et al. "Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases." Cancer vol. 83,7 (1998): 1292-9.
- Savera, A T et al. "Immunolocalization of three novel smooth muscle-specific proteins in salivary gland pleomorphic adenoma: assessment of the morphogenetic role of myoepithelium." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 10,11 (1997): 1093-100.
- Hornick, Jason L, and Christopher D M Fletcher. "Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters." The American journal of surgical pathology vol. 27,9 (2003): 1183-96.
Specifications
- Reactivity: paraffin
- Control: Appendix (Cytoplasmic)
- Dilution Range: 1:50-1:200 *
Package Inserts
IFU
- IVD Rev. 6.0 (CMC23131060)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 231R-14 |
| 0.5 mL concentrate | 231R-15 |
| 1.0 mL concentrate | 231R-16 |
| 1.0 mL predilute ready-to-use | 231R-17 |
| 7.0 mL predilute ready-to-use | 231R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 231R-14 |
| 0.5 mL concentrate | 231R-15 |
| 1.0 mL concentrate | 231R-16 |
| 1.0 mL predilute ready-to-use | 231R-17 |
| 7.0 mL predilute ready-to-use | 231R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 231R-14 |
| 0.5 mL concentrate | 231R-15 |
| 1.0 mL concentrate | 231R-16 |
| 1.0 mL predilute ready-to-use | 231R-17 |
| 7.0 mL predilute ready-to-use | 231R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 231R-14-RUO |
| 0.5 mL concentrate (RUO) | 231R-15-RUO |
| 1.0 mL concentrate (RUO) | 231R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 231R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 231R-18-RUO |
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