Cell Marque Portfolio

MSH6 (44)

Mouse Monoclonal


MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as Hereditary Non-Polyposis Colon Cancer (HNPCC). The anti-MSH6 antibody is useful in screening patients and families for this condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.

Specialties: Gastrointestinal (GI) Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon, colon carcinoma
  • Isotype: IgG1
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Leica Bond
    Protocol F: ER2/20
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

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Keycode Specific IFU

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*Note: IFUs with the prefix RUO or ASR are only available for download in English.


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References


  1. Lagerstedt Robinson K, et al. J Natl Cancer Inst. 2007; 99:291-9.
  2. Niessen RC, et al. Gut. 2006; 55:1781-8.
  3. Hansen TP, et al. Appl Immunohistochem Mol Morphol. 2006; 14:115-21.
  4. Lawes DA, et al. Br J Cancer. 2005; 93:472-7.
  5. Stormorken AT, et al. J Clin Oncol. 2005; 23:4705-12.
  6. Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.

Last updated: 2017-05-24 08:46:09

MSH6
Nuclear staining by MSH6 antibody on well differentiated colon adenocarcinoma.

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Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon, colon carcinoma
  • Isotype: IgG1
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Leica Bond
    Protocol F: ER2/20
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

References


  1. Lagerstedt Robinson K, et al. J Natl Cancer Inst. 2007; 99:291-9.
  2. Niessen RC, et al. Gut. 2006; 55:1781-8.
  3. Hansen TP, et al. Appl Immunohistochem Mol Morphol. 2006; 14:115-21.
  4. Lawes DA, et al. Br J Cancer. 2005; 93:472-7.
  5. Stormorken AT, et al. J Clin Oncol. 2005; 23:4705-12.
  6. Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.

Download an IFU

Select revision:


Download SDS


Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 287M-14
0.5 ml, concentrate 287M-15
1 ml, concentrate 287M-16
1 ml, predilute 287M-17
7 ml, predilute 287M-18
25 ml, predilute 287M-10

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 287M-14
0.5 ml, concentrate 287M-15
1 ml, concentrate 287M-16
1 ml, predilute 287M-17
7 ml, predilute 287M-18
25 ml, predilute 287M-10

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 287M-14
0.5 ml, concentrate 287M-15
1 ml, concentrate 287M-16
1 ml, predilute 287M-17
7 ml, predilute 287M-18
25 ml, predilute 287M-10

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 287M-14-RUO
0.5 ml, concentrate 287M-15-RUO
1 ml, concentrate 287M-16-RUO
1 ml, predilute 287M-17-RUO
7 ml, predilute 287M-18-RUO
25 ml, predilute 287M-10-RUO

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon, colon carcinoma
  • Isotype: IgG1
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Leica Bond
    Protocol F: ER2/20
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

Download SDS

References


  1. Lagerstedt Robinson K, et al. J Natl Cancer Inst. 2007; 99:291-9.
  2. Niessen RC, et al. Gut. 2006; 55:1781-8.
  3. Hansen TP, et al. Appl Immunohistochem Mol Morphol. 2006; 14:115-21.
  4. Lawes DA, et al. Br J Cancer. 2005; 93:472-7.
  5. Stormorken AT, et al. J Clin Oncol. 2005; 23:4705-12.
  6. Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
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