MSH6 (44) Mouse Monoclonal Antibody

MSH6
Nuclear staining by MSH6 antibody on well differentiated colon adenocarcinoma.

MSH6 (44) Mouse Monoclonal Antibody

Specialties: Gastrointestinal (GI) Pathology

Updated: 2018-01-11 12:14:57

MSH6 is a mismatch repair protein which is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been suggested that the deficiencies in DNA mismatch repair protein(s) can be seen in some malignancies such as hereditary nonpolyposis colorectal cancer (HNPCC) and endometrial cancer. Anti-MSH6 may be useful in the identification of the MSH6 protein in a variety of normal and neoplastic tissues and the  identification of loss of MSH6 in tumors with MSI genotype.1-6 Anti-MSH6 is best utilized in an IHC panel that includes anti-MLH1, anti-MSH2, and anti-PMS2.

  1. Lagerstedt Robinson K, et al. Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics. J Natl Cancer Inst. 2007; 99: 291-9.
  2. Niessen RC, et al. Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis colorectal cancer. Gut. 2006; 55:1781-8.
  3. Hansen TP, et al. Optimization of antibodies for detection of the mismatch repair proteins MLH1, MSH2, MSH6, and PMS2 using a biotin-free visualization system. Appl Immunohistochem Mol Morphol. 2006; 14:115-21.
  4. Lawes DA, et al. The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers. Br J Cancer. 2005; 93:472-7.
  5. Stormorken AT, et al. Immunohistochemistry identifies carriers of mismatch repair gene defects causing hereditary nonpolyposis colorectal cancer. J Clin Oncol. 2005; 23:4705-12.
  6. Rigau V, et al. Microsatellite instability in colorectal carcinoma. The comparison of immunohistochemistry and molecular biology suggests a role for hMSH6 [correction of hMLH6] immunostaining. Arch Pathol Lab Med. 2003; 127:694-700.

Specifications


  • Reactivity: paraffin
  • Control: Colon (Nuclear); Colon carcinoma (Nuclear)
  • Dilution Range: 1:25-1:100 *

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25.0 mL predilute ready-to-use287M-10
0.1 mL concentrate287M-14
0.5 mL concentrate287M-15
1.0 mL concentrate287M-16
1.0 mL predilute ready-to-use287M-17
7.0 mL predilute ready-to-use287M-18

For in vitro diagnostic (IVD) use in Canada

25.0 mL predilute ready-to-use287M-10
0.1 mL concentrate287M-14
0.5 mL concentrate287M-15
1.0 mL concentrate287M-16
1.0 mL predilute ready-to-use287M-17
7.0 mL predilute ready-to-use287M-18

For in vitro diagnostic (IVD) use in Europe

25.0 mL predilute ready-to-use287M-10
0.1 mL concentrate287M-14
0.5 mL concentrate287M-15
1.0 mL concentrate287M-16
1.0 mL predilute ready-to-use287M-17
7.0 mL predilute ready-to-use287M-18

For research use only (RUO) in Japan

25.0 mL predilute ready-to-use (RUO)287M-10-RUO
0.1 mL concentrate (RUO)287M-14-RUO
0.5 mL concentrate (RUO)287M-15-RUO
1.0 mL concentrate (RUO)287M-16-RUO
1.0 mL predilute ready-to-use (RUO)287M-17-RUO
7.0 mL predilute ready-to-use (RUO)287M-18-RUO

 

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