p27Kip1 (SX53G8) Mouse Monoclonal Antibody

p27<sup>Kip1</sup>
p27 antibody labels the nuclei of most mature lymphocyte in the paracrotical and intracortical region, as well as squamous epithelial nuclei.

p27Kip1 (SX53G8) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

p27Kip1, also known as cyclin-dependent kinase inhibitor 1B (CDNK1B), is a kinase inhibitor that controls cell cycle progression.1-4 p27Kip1 is involved in G1 phase arrest and obstructs cell entry into the S phase by binding to and inhibiting cyclin E-CDK2, effectively slowing or stopping the cell division cycle.1-4 p27Kip1 is broadly expressed in normal tissue but can be dysfunctional in neoplastic tissue and, therefore, not expressed.1-2

  1. Polyak K, et al. Cell. 1994; 78:59-66.
  2. Sun C, et al. AM J Cancer Res. 2016; 6:2207-20.
  3. Sangfelt O, et al. Oncogene. 1999; 18:2798-810.
  4. Hsieh FF, et al. Blood. 2000; 96:2746-54.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: tonsil
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate427M-94
0.5 mL concentrate427M-95
1 mL concentrate427M-96
1 mL predilute427M-97
7 mL predilute427M-98

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate427M-94
0.5 mL concentrate427M-95
1 mL concentrate427M-96
1 mL predilute427M-97
7 mL predilute427M-98

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate427M-94
0.5 mL concentrate427M-95
1 mL concentrate427M-96
1 mL predilute427M-97
7 mL predilute427M-98

For research use only (RUO) in Japan

0.1 mL concentrate427M-94-RUO
0.5 mL concentrate427M-95-RUO
1 mL concentrate427M-96-RUO
1 mL predilute427M-97-RUO
7 mL predilute427M-98-RUO

 

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