MART-1 (M2-7C10) + Tyrosinase (T311) Mouse Monoclonal Antibody

MART-1 (M2-7C10) + Tyrosinase (T311)
MART-1 (Melan A) + Tyrosinase (M2-7C10 + T311) on melanoma.

MART-1 (M2-7C10) + Tyrosinase (T311) Mouse Monoclonal Antibody

Specialties: Dermatopathology

Updated: 2017-05-25 14:41:33

MART-1 (also known as Melan A) is a melanocyte differentiation antigen. It is present in melanocytes of normal skin, retina, nevi and in the majority of melanomas. Tyrosinase is an enzyme integral in the process of melanin synthesis, and found in most malignant melanomas. Therefore, this cocktail is useful for the identification of melanomas and melanocytic lesions.1-7

  1. Orchard G. Evaluation of melanocytic neoplasms: application of a pan-melanoma antibody cocktail. Br J Biomed Sci. 2002; 59:196-202.
  2. Prasad ML, et al. Expression of melanocytic differentiation markers in malignant melanomas of the oral and sinonasal mucosa. Am J Surg Pathol. 2001; 25:782-7.
  3. de Vries TJ, et al. Expression of gp100, MART-1, tyrosinase, and S100 in paraffin-embedded primary melanomas and locoregional, lymph node, and visceral metastases: implications for diagnosis and immunotherapy. A study conducted by the EORTC Melanoma Cooperative Group. J Pathol. 2001; 193:13-20.
  4. Yaziji H, et al. Immunohistochemical markers of melanocytic tumors. In J Surg Pathol. 2003; 11:11-5.
  5. Shidham VB, et al. Improved immunohistochemical evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma with 'MCW melanoma cocktail'--a mixture of monoclonal antibodies to MART-1, Melan-A, and tyrosinase. BMC Cancer. 2003; 3:15.
  6. Hoang MP, et al. Recurrent melanocytic nevus: a histologic and immunohistochemical evaluation. J Cutan Pathol. 2001; 28:400-6.
  7. Ordóñez NG. Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma: a review and update. Hum Pathol. 2014; 45:191-205.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: normal skin, melanoma
  • Dilution Range: N/A*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

1 mL predilute903H-07
7 mL predilute903H-08

For in vitro diagnostic (IVD) use in Canada

1 mL predilute903H-07
7 mL predilute903H-08

For in vitro diagnostic (IVD) use in Europe

1 mL predilute903H-07
7 mL predilute903H-08

For research use only (RUO) in Japan

1 mL predilute903H-07-RUO
7 mL predilute903H-08-RUO

 

To request information on this product in additional countries, please click the button below.

Request More Information