ZAP-70 (2F3.2) Mouse Monoclonal Antibody

ZAP-70
Nuclear and cytoplasmic labelling of chronic lymphocytic leukemia cells by ZAP-70 antibody.

ZAP-70 (2F3.2) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

Zeta-associated protein-70 (ZAP-70) is a member of the Syk family of tyrosine kinases, a group of proteins that attach to the zeta chain components of T-cell receptors to signal downstream events involved in the regulation of cell function, proliferation, and death.1  Research suggests that the ZAP-70 protein may also play an important role in natural killer (NK) cell activation and early B-cell development; however, it is not expressed in most normal mature B-cells.1 Expression of ZAP-70 has been reported in various lymphomas, including mantle cell lymphoma, small lymphocytic lymphoma and marginal zone lymphoma.1, 2

  1. Admirand J, et al. Immunohistochemical detection of ZAP-70 in 341 cases of non-Hodgkin and Hodgkin lymphoma. Modern Pathology. 2004; 17:954-61.
  2. Carreras J, et al. Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms. J Pathol. 2005; 205:507-13.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: chronic lymphocytic leukemia/small lymphocytic lymphoma, tonsil
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate349M-94
0.5 mL concentrate349M-95
1 mL concentrate349M-96
1 mL predilute349M-97
7 mL predilute349M-98

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate349M-94
0.5 mL concentrate349M-95
1 mL concentrate349M-96
1 mL predilute349M-97
7 mL predilute349M-98

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate349M-94
0.5 mL concentrate349M-95
1 mL concentrate349M-96
1 mL predilute349M-97
7 mL predilute349M-98

This product is not available in Japan

 

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