TRAcP (9C5) Mouse Monoclonal Antibody

TRAcP
The cytoplasm of Hairy cell leukemia cells are labelled by anti-TRAcP.

TRAcP (9C5) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

The type-5 tartrate resistant acid phosphatase (TRAcP) is an iron-binding glycoprotein that exists in humans as distinct unprocessed and processed isoforms, 5a and 5b, respectively. TRAcP is principally expressed in cells of the monocyte lineage, including macrophages, dendritic cells, and osteoclasts, with its most well understood function being in facilitating the bone resorption process.1 A variety of hematological disorders display TRAcP activity but antibodies developed against the protein have a particularly high sensitivity and specificity for labeling hairy cells in patient cases of hairy cell leukemia.2-4  Anti-TRAcP has immunohistochemical utility in providing adjunctive information for the identification of hairy cell leukemia.

  1. Janckila, AJ, et al. Biology and clinical significance of tartrate-resistant acid phosphatases: new perspectives on an old enzyme. Calcif Tissue Int. 2009; 85:465-83.
  2. Hayman AR. Tartrate-resistant acid phosphatase (TRAP) and the osteoclast/immune cell dichotomy. Autoimmunity. 2008; 41:218-23.
  3. Hoyer, JD, et al. Immunohistochemical demonstration of acid phosphatase isoenzyme 5 (tartrate-resistant) in paraffin sections of hairy cell leukemia and other hematologic disorders. Am J Clin Pathol. 1997; 108:308-15.
  4. Janckila, AJ, et al. Hairy cell identification by immunohistochemistry of tartrate-resistant acid phosphatase. Blood. 1995; 85:2839-44.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: hairy cell leukemia
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate341M-94
0.5 mL concentrate341M-95
1 mL concentrate341M-96
1 mL predilute341M-97
7 mL predilute341M-98

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate341M-94
0.5 mL concentrate341M-95
1 mL concentrate341M-96
1 mL predilute341M-97
7 mL predilute341M-98

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate341M-94
0.5 mL concentrate341M-95
1 mL concentrate341M-96
1 mL predilute341M-97
7 mL predilute341M-98

For research use only (RUO) in Japan

0.1 mL concentrate341M-94-RUO
0.5 mL concentrate341M-95-RUO
1 mL concentrate341M-96-RUO
1 mL predilute341M-97-RUO
7 mL predilute341M-98-RUO

 

To request information on this product in additional countries, please click the button below.

Request More Information