Cell Marque Portfolio

MSH2 (G219-1129)

Mouse Monoclonal


MSH2 is a mismatch repair protein which is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been suggested that the deficiencies in DNA mismatch repair protein(s) can be seen in some malignancies such as hereditary nonpolyposis colorectal cancer (HNPCC) and endometrial cancer. Anti-MSH2 may be useful in identification of MSH2 protein in variety of normal and neoplastic tissues and identification of loss of MSH2 in tumors with MSI genotype.1-8 Anti-MSH2 is best utilized in an IHC panel that includes anti-MLH1, anti-MSH6, and anti-PMS2.

Specialties: Gastrointestinal (GI) Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon mucosa, colon carcinoma
  • Isotype: IgG1
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/Perm Red
  • Ventana OptiView
    OV/CC1(32min)/8min @ 37°C
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

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*Note: IFUs with the prefix RUO or ASR are only available for download in English.


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References


  1. Wright CL, et al. Am J Surg Pathol. 2003; 27:1393-1406.
  2. Brueckl WM, et al. Anticancer Research. 2003; 23:1773-1778.
  3. Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
  4. Renkonen E, et al. J Clin Oncol. 2003; 21:3629-3637.
  5. Hoedema R, et al. The American Surgeon. 2003; 69:387-92.
  6. Christensen M, et al. Cancer. 2002; 95:2422-30.
  7. Wahlberg SS, et al. Cancer Research. 2002; 62:3485-3492.
  8. Lanza G, et al. Modern Pathology. 2002; 15:741-749.

Last updated: 2016-09-29 13:18:40

MSH2
Anti-MSH2 positively labels well differentiated colon adenocarcinoma in a nuclear pattern.

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Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon mucosa, colon carcinoma
  • Isotype: IgG1
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/Perm Red
  • Ventana OptiView
    OV/CC1(32min)/8min @ 37°C
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

References


  1. Wright CL, et al. Am J Surg Pathol. 2003; 27:1393-1406.
  2. Brueckl WM, et al. Anticancer Research. 2003; 23:1773-1778.
  3. Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
  4. Renkonen E, et al. J Clin Oncol. 2003; 21:3629-3637.
  5. Hoedema R, et al. The American Surgeon. 2003; 69:387-92.
  6. Christensen M, et al. Cancer. 2002; 95:2422-30.
  7. Wahlberg SS, et al. Cancer Research. 2002; 62:3485-3492.
  8. Lanza G, et al. Modern Pathology. 2002; 15:741-749.

Download an IFU

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 286M-14
0.5 ml, concentrate 286M-15
1 ml, concentrate 286M-16
1 ml, predilute 286M-17
7 ml, predilute 286M-18
25 ml, predilute 286M-10

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 286M-14
0.5 ml, concentrate 286M-15
1 ml, concentrate 286M-16
1 ml, predilute 286M-17
7 ml, predilute 286M-18
25 ml, predilute 286M-10

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 286M-14
0.5 ml, concentrate 286M-15
1 ml, concentrate 286M-16
1 ml, predilute 286M-17
7 ml, predilute 286M-18
25 ml, predilute 286M-10

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 286M-14 (RUO)
0.5 ml, concentrate 286M-15 (RUO)
1 ml, concentrate 286M-16 (RUO)
1 ml, predilute 286M-17 (RUO)
7 ml, predilute 286M-18 (RUO)
25 ml, predilute 286M-10 (RUO)

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon mucosa, colon carcinoma
  • Isotype: IgG1
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/DAB
  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/Perm Red
  • Ventana OptiView
    OV/CC1(32min)/8min @ 37°C
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

References


  1. Wright CL, et al. Am J Surg Pathol. 2003; 27:1393-1406.
  2. Brueckl WM, et al. Anticancer Research. 2003; 23:1773-1778.
  3. Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
  4. Renkonen E, et al. J Clin Oncol. 2003; 21:3629-3637.
  5. Hoedema R, et al. The American Surgeon. 2003; 69:387-92.
  6. Christensen M, et al. Cancer. 2002; 95:2422-30.
  7. Wahlberg SS, et al. Cancer Research. 2002; 62:3485-3492.
  8. Lanza G, et al. Modern Pathology. 2002; 15:741-749.
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