Insulin Guinea Pig Polyclonal Antibody

Insulin
Pancreatic islet cells express insulin in a cytoplasmic pattern.

Insulin Guinea Pig Polyclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Insulin is a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Immunohistochemical investigations have localized insulin in the beta cells of pancreatic islets of Langerhans. Insulin is also present in tumors of beta cell origin such as insulinoma. The presence of insulin in the cytoplasm of islet tumors is the most reliable indication of functional insulinomas.1-4

  1. Akagi T, et al. Cancer. 1981; 47:417-24.
  2. Erlandsen SL. Monogr Pathol. 1980; 21:140-55.
  3. Azzoni C, et al. Virchows Arch. 1998; 433:495-504.
  4. Lubensky IA, et al. Am J Pathol. 1998; 153:223-31.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: pancreas
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate273A-14
0.5 mL concentrate273A-15
1 mL concentrate273A-16
1 mL predilute273A-17
7 mL predilute273A-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate273A-14
0.5 mL concentrate273A-15
1 mL concentrate273A-16
1 mL predilute273A-17
7 mL predilute273A-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate273A-14
0.5 mL concentrate273A-15
1 mL concentrate273A-16
1 mL predilute273A-17
7 mL predilute273A-18

For research use only (RUO) in Japan

0.1 mL concentrate273A-14-RUO
0.5 mL concentrate273A-15-RUO
1 mL concentrate273A-16-RUO
1 mL predilute273A-17-RUO
7 mL predilute273A-18-RUO

 

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