| Cytokeratin 5 + Cytokeratin 14 |  |
Cytokeratin 5 (CK5) is an intermediate filament protein of 58kD molecular weight. It is a type II (basic) cytokeratin. Antibodies to this protein identify basal cells of squamous and glandular epithelia, myoepithelia, and mesothelium. Cytokeratin 14 (CK14) is a 50 kD polypeptide found in basal cell of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells.
Anti-Cytokeratin 5 has been useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelial mesothelioma. Almost all squamous cell carcinomas, about half of transitional carcinomas, and many undifferentiated large cell carcinomas immunostain with anti-CK5. Anti-CK14 has been demonstrated to be useful in differentiating squamous cell carcinomas from other epithelial tumors. Anti-CK5, along with Anti-CK14, has found application in identifying the basaloid phenotype of breast carcinoma, a tumor with poor prognosis.
Rabbit & Mouse Cocktail,
Clones: EP1601Y + LL002| | 1 ml prediluted | 905H-07 | | | 7 ml prediluted | 905H-08 | | |
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Regulatory Status
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