| Claudin 1 |  |
The claudins are a family of over twenty proteins which are components of tight junction. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. The claudins constitute a variable component, with specific claudins being associated with specific tissues.
The immunoreactivity for anti-claudin 1 is membranous and is found in nearly all carcinomas. The staining is much stronger in the carcinoma cells than in normal tissues. Anti-claudin 1 in a panel of immunostains with EMA (positive), S-100 (negative), and GLUT1 can be utilized as a robust marker in diagnosis of perineurioma and neurofibroma. Recently studies showed anti-claudin seems to be a specific marker for meningiomas. Therefore, anti-claudin with anti-EMA, anti-S-100 protein, anti-CD34, and anti-glial fibrillary acidic protein may be helpful in the diagnosis of meningiomas from histologic mimics.
Rabbit Polyclonal| | 0.1 ml concentrated | 359A-14 | | | 0.5 ml concentrated | 359A-15 | | | 1 ml concentrated | 359A-16 | | | 1 ml prediluted | 359A-17 | | | 7 ml prediluted | 359A-18 | | | 5 Positive Control Slides | 359S | | |
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