| TCL1 |  |
T-cell leukemia/lymphoma protein 1 (TCL1, TCL1A, p14TCL1) is a 14kDa product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (T-PLL). TCL1 protein is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. Chromosomal translocations may lead to overexpression of TCL1, resulting in T-cell leukemia and B-cell lymphoma. TCL1 binds to a novel site in the pleckstrin homology (PH) domain, resulting in activation and nuclear translocation of Akt by overexpressed TCL1 which may promote an anti-apoptotic response; this may normally serve to promote growth during development but may lead to malignancy when TCL1 is overexpressed. TCL1 is expressed in more differentiated B-cells, under both reactive and neoplastic conditions, from antigen committed B-cells and in germinal center B-cells. TCL1 is down-regulated in the latest stage of B-cell differentiation.
TCL1 is overexpressed in Burkitt Lymphoma, the majority of AIDS-related non-Hodgkin's Lymphoma-designated immunoblastic plasmacytoid lymphoma, lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and primary cutaneous B-cell lymphoma. Therefore, the most useful application of anti-TCL1 is the discrimination of B-cell lymphomas from T-cell lymphomas, CD30+ anaplastic large cell lymphomas, multiple myeloma, and marginal zone B-cell lymphoma.
Mouse Monoclonal, Clone: MRQ-7| | 0.1 ml concentrated | 357M-14 | | | 0.5 ml concentrated | 357M-15 | | | 1 ml concentrated | 357M-16 | | | 1 ml prediluted | 357M-17 | | | 7 ml prediluted | 357M-18 | | | 5 Positive Control Slides | 357S | | |
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