| p120 Catenin |  |
p120 Catenin is encoded on chromosome 11q11. Alpha-catenin and Beta-Catenin bind to the intracellular domain of E-Cadherin while p120 Catenin binds E-Cadherin at a juxta-membrane site. The complex stabilizes tight junctions. In the cell, p120 Catenin localized to the E-Cadherin/catenins cell adhesion complex, directly associates with cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. A deficiency of E-Cadherin results in the intracytoplasmic accumulation of p120 Catenin. Lobular carcinoma of the breast shows intracytoplasmic accumulation of p120 Catenin while ductal carcinoma shows reduced membrane p120 Catenin without cytoplasmic accumulation. In gastric and colonic carcinoma, strong cytoplasmic p120 Catenin is associated with dyscohesive infiltrative morphology. The high expression of p120 may indicate poor prognosis in lung adenocarcinoma, bladder cancer, pancreatic cancer.
Mouse Monoclonal, Clone: MRQ-5
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Regulatory Status
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