| FOXP1 |  |
The FOXP1 gene is located at 3p13 and codes for a member of the FOX family of transcription factors. The proteins in this family take part in a wide range of normal developmental events, including the control of cellular differentiation and proliferation, immune regulation, and signal transduction. FOX transcription factors are implicated in carcinogenesis through retroviral integration, transcriptional regulation, chromosomal translocation, and gene amplification.
FOXP1 is expressed in normal activated B cells in the mantle zone and germinal center (lymph node). FOXP1 nuclear labeling in diffuse large B-cell lymphoma (DLBCL) has been associated with a poor overall survival in studies by A H Banham el al and S L Barrans et al. FOXP1 expression in mucosa-associated lymphoid tissue lymphomas was also associated with transformation to diffuse large B-cell lymphoma in a study by X Sagaert et al.
In the setting of primary cutaneous lymphoma, FOXP1 expression is found in the B-cell lymphoma, leg type and may serve as an additional diagnostic marker for this entity.
Rabbit Polyclonal| | 0.1 ml concentrated | 350A-14 | | | 0.5 ml concentrated | 350A-15 | | | 1 ml concentrated | 350A-16 | | | 1 ml prediluted | 350A-17 | | | 7 ml prediluted | 350A-18 | | | 5 Positive Control Slides | 350S | | |
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